New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII) - Wikidata - awgldk - TriplyDB

New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)

New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)

http://www.wikidata.org/entity/Q27016402

about

The emerging role of CaMKII in cancer Mechanisms of altered Ca²⁺ handling in heart failure Mechanisms of sudden cardiac death: oxidants and metabolism CaMKII-dependent responses to ischemia and reperfusion challenges in the heart.Mitochondria and arrhythmias.Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.Novel aspects of excitation-contraction coupling in heart failure.MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1.PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ.The Use of Gene Therapy for Ablation of Atrial Fibrillation.Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts.At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.Electrical storm: recent pathophysiological insights and therapeutic consequences.Ca(2+) /calmodulin dependent kinase II: a critical mediator in determining reperfusion outcomes in the heart?Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.CaMKII activation promotes cardiac electrical remodeling and increases the susceptibility to arrhythmia induction in high fat diet-fed mice with hyperlipidemia conditions.Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.CaMKII is a nodal signal for multiple programmed cell death pathways in heart.Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent.Mitochondrial Ca2+ uniporter and CaMKII in heart.Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.Stress Signaling JNK2 Crosstalk with CaMKII Underlies Enhanced Atrial Arrhythmogenesis.[Remodeling of the aging heart : Sinus node dysfunction and atrial fibrillation].Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca/calmodulin-dependent protein kinase II Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy

P2860

Q26995205-72BB5553-3407-4271-8553-FEC0F4425AB9 Q27012758-8F203FEE-7FF4-498E-8465-14D4C8D060F5 Q27024176-210C5325-33F2-491D-8D56-C30CD45E6BC4 Q33600515-988ED42C-B0BF-463D-B024-4714D2AADFE4 Q33896746-0091D8AB-FF7B-4D50-B8AF-DC5288656D82 Q33957736-E3E17F70-ED5E-48A4-8410-ED0832A63C06 Q34002408-C0ED9B5A-6AA0-407B-914C-CB986439CA1B Q34004829-AC8DD7C2-5A59-4E24-A755-2CC5355E51E1 Q34387308-6C9F8803-E6BA-47F8-86D6-67E7E5441BB9 Q34603278-CBC2A39C-6AF1-4475-9874-AC777CD82F15 Q34652710-8E2F67DC-6BD0-4B88-8491-E2A9C223681E Q35197492-A9BDCC14-88B8-44AE-A36B-49C9D8A43D04 Q36040250-01724376-A34F-4E27-8BFA-A268A8BA8B6D Q36283384-F6C60018-14C5-45C3-B91E-8823BCCB926F Q36458906-266C106A-8399-4DB4-9089-77F137CD31DB Q36650585-14BF477C-E167-4C1F-909D-801D26474EBF Q37210184-4AE467DB-685D-4F37-9E00-259921E34CF4 Q37331050-23BC92F5-DA95-4ADC-86F4-76980BFCA95D Q37366218-550ED472-6396-416C-A601-AC4ED4992B0F Q37511850-6D663D4A-932A-49CD-B750-D21110377498 Q37655174-B3A6C0EF-1BB2-40B1-86FB-86ECFB89EE48 Q37695297-6087E5A1-69AE-4EA3-BAC3-545FAFB28F4C Q38083549-D97AB321-5CF4-4D3E-BAD1-6BA0DE23EFFF Q38256772-0FAA41BA-0B59-433E-A94B-707C4A967ED8 Q38631812-9D4D48E0-00B8-4455-A76B-186E3D93EF6B Q38702432-8F1E6B47-FC29-4AC6-BF7B-27A4B94D43E0 Q38795286-C0BCC60E-324F-4B2E-ABA2-1F38F7D28CE4 Q39056528-4B088FB7-5326-4A6C-9D18-2BE5F6ED67C1 Q39781629-261721BC-C940-4348-B106-E22D929F98A4 Q40722220-05F34E97-29D8-49DB-8CA6-4CD68068BC1C Q41016215-2057536A-20B4-44AD-8D42-64CBDDAF7C74 Q41273205-51C00FD1-70DD-437F-8DE3-A00CE39CB273 Q42413006-6BD33A62-083A-45EF-BB27-2CFD96CE95DD Q42551776-407B4D89-882B-459C-BBA1-AAC376B730D5 Q47708298-E972D7F6-DA0F-4A3A-828A-580E54F7F340 Q49912067-414D26F5-40E6-4339-A669-1DBDB2EFE77E Q51840493-6833F82C-9350-4BD0-B717-CCDDE70EFF83 Q52707811-51EA50D9-7A2E-4CC2-A6C9-E3BF8EC4E43A Q58718425-9C398FB2-9267-43DD-B769-128B4AC38178 Q58797256-32C555F4-C876-4653-94CA-D854FD89F1AE

P2860

New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)

http://www.wikidata.org/entity/Q27016402

description

2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@ast

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@en

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@nl

type

label

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@ast

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@en

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@nl

prefLabel

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@ast

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@en

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@nl

P1433

Q27016402-07A167E3-EF9A-4F30-A10E-0D848AC4CF59

P1476

Q27016402-7B266ACB-FA7F-4D94-A6AB-88093C8C31CD

P2093

Q27016402-033ED883-F323-4CB5-9FBB-D5A1D111B0FE

Q27016402-C76F2E0E-0599-4F65-A99F-7475840CE61D

P2860

Q27016402-015FC93E-1609-4DE5-80F4-D561C2925FF9

Q27016402-0480417D-73B1-4979-9243-6080D4009FE2

Q27016402-06612B2C-CCAF-4B13-BBC6-7FCD3464C9A1

Q27016402-0899C9AC-1C12-446F-B525-93011A4D6E85

Q27016402-08AB7194-D774-45B4-A13E-0C19032B9228

Q27016402-0970056E-9713-4D4A-A6A1-D23468B3D9FD

Q27016402-0A4965D8-07E7-4771-9776-77A80C77FDF6

Q27016402-0BF72254-D744-46AE-81E8-F1E2C9FF20FA

Q27016402-0FE979CB-3BBE-4440-8017-251A86E2DF71

Q27016402-141F882F-D47D-4E96-80E8-444DCCCAE1E9

P304

Q27016402-217BE1C6-0E51-468B-80B2-AD57B0762015

P31

Q27016402-52C946F8-50B7-4E54-AE90-7D9FDD3AF2DB

P356

Q27016402-21EF26D6-B425-4FC0-952B-2374E66F9B7A

P407

Q27016402-D5A1090B-96A5-4583-9A03-2969E6113806

P433

Q27016402-912B451B-E29F-492F-9BD1-33ACD74400CF

P478

Q27016402-81DD4BD8-A1FB-4FAE-BF6A-89EA049D1D6F

P577

Q27016402-D4559DC1-62DF-4067-B519-FB5DCD226585

P5875

Q27016402-73F38EF6-5E63-4AAD-BDCD-D37DC3B4727D

P698

Q27016402-B44C749B-CD4A-49F7-965B-B8921B529D11

P921

Q27016402-AE99A241-68D3-4B2C-BB4B-184E04ED4929

P932

Q27016402-FFF94345-7DE2-4D5D-BC60-9D5BD0DE4875

P356

CIRCULATIONAHA.112.124990

P1433

P1476

New therapeutic targets in car ...... n-dependent kinase II (CaMKII)

@en

P2093

A. G. Rokita

http://www.w3.org/2001/XMLSchema#string

M. E. Anderson

http://www.w3.org/2001/XMLSchema#string

P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

X-ray structure of a voltage-dependent K+ channel

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

P304

2125-39

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1161/CIRCULATIONAHA.112.124990

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

126

http://www.w3.org/2001/XMLSchema#string

P577

2012-10-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

232611533

http://www.w3.org/2001/XMLSchema#string

P698

23091085

http://www.w3.org/2001/XMLSchema#string

P921

heart arrhythmia

P932

3532717

http://www.w3.org/2001/XMLSchema#string