Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling.
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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channelsMode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channelsStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelMolecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturationThe murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotidesFear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.Serotonin modulates spike probability in the axon initial segment through HCN channels.Differential excitability and modulation of striatal medium spiny neuron dendritesDendritic ion channel trafficking and plasticity.Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampusInterneurons of the cerebellar cortex toggle Purkinje cells between up and down states.Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.Functional expression of the human HCN3 channel.Ih tunes theta/gamma oscillations and cross-frequency coupling in an in silico CA3 model.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Cellular and network mechanisms of genetically-determined absence seizures.Dichotomous anatomical properties of adult striatal medium spiny neurons.Allosteric modulation of ion channels: the case of maxi-K.Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides.Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker propertiesFiring rate and pattern heterogeneity in the globus pallidus arise from a single neuronal population.Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons.Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks.TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMPEngineering a biological pacemaker: in vivo, in vitro and in silico modelsHCN and KV7 (M-) channels as targets for epilepsy treatment.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration.Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels.Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.
P2860
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P2860
Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Activity-dependent regulation ...... h dynamic allosteric coupling.
@en
Activity-dependent regulation ...... h dynamic allosteric coupling.
@nl
type
label
Activity-dependent regulation ...... h dynamic allosteric coupling.
@en
Activity-dependent regulation ...... h dynamic allosteric coupling.
@nl
prefLabel
Activity-dependent regulation ...... h dynamic allosteric coupling.
@en
Activity-dependent regulation ...... h dynamic allosteric coupling.
@nl
P2093
P1433
P1476
Activity-dependent regulation ...... h dynamic allosteric coupling.
@en
P2093
Steven A Siegelbaum
P304
P356
10.1016/S0896-6273(02)00968-6
P407
P577
2002-10-01T00:00:00Z