Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
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Development of bisphosphonates.Bisphosphonates: mechanism of action and role in clinical practiceThe bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statinsInnovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis PathwayModulation of osteoclast differentiation and bone resorption by Rho GTPasesBisphosphonates in breast cancerMechanisms of bone anabolism regulated by statinsDiagnosis and treatment of bone disease in multiple myeloma: spotlight on spinal involvementTranscription Adaptation during In Vitro Adipogenesis and Osteogenesis of Porcine Mesenchymal Stem Cells: Dynamics of Pathways, Biological Processes, Up-Stream Regulators, and Gene NetworksBone healing in 2016Review of risedronate in the treatment of osteoporosisBisphosphonates: from bench to bedsideBisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell lineThe bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxelCalcitonin inhibits SDCP-induced osteoclast apoptosis and increases its efficacy in a rat model of osteoporosisEndocytotic uptake of zoledronic acid by tubular cells may explain its renal effects in cancer patients receiving high doses of the compoundAssessment of FBA Based Gene Essentiality Analysis in Cancer with a Fast Context-Specific Network Reconstruction MethodSynergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblastsZoledronic acid preserves bone structure and increases survival but does not limit tumour incidence in a prostate cancer bone metastasis modelrDrak1, a novel kinase related to apoptosis, is strongly expressed in active osteoclasts and induces apoptosis.Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells.New symmetrically esterified m-bromobenzyl non-aminobisphosphonates inhibited breast cancer growth and metastases.Anti-tumour activity of bisphosphonates in human myeloma cells.Effect of atorvastatin on orthodontic tooth movement in male wistar rats.Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk.The pharmacology of bisphosphonates and new insights into their mechanisms of action.The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.A pilot study of zoledronic acid in the treatment of patients with advanced malignant pleural mesothelioma.Reduced osteoclastogenesis and RANKL expression in marrow from women taking alendronate.Osteonecrosis of the jaw in a patient on Denosumab.Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results. International Bone and Cancer Study Group (IBCG).Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitoninStatins and bones.Can an anti-fracture agent heal fractures?Periprosthetic bone density as outcome of therapeutic response.Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma.Bisphosphonates and the prevention of metastasis: first evidences from preclinical and clinical studies.Alendronate treatment improves bone-pedicle screw interface fixation in posterior lateral spine fusion: an experimental study in a porcine modelMechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro.
P2860
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P2860
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@en
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@nl
type
label
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@en
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@nl
prefLabel
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@en
Nitrogen-containing bisphospho ...... nding proteins, including Ras.
@nl
P2093
P1476
Nitrogen-containing bisphospho ...... inding proteins, including Ras
@en
P2093
P2860
P304
P356
10.1359/JBMR.1998.13.4.581
P577
1998-04-01T00:00:00Z