Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.
about
Recognition of enzymes lacking bound cofactor by protein quality control.Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).Evolutionary Divergent Suppressor Mutations in Conformational DiseasesExperimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases
P2860
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P2860
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Conformational dynamics is key ...... on by pharmacological ligands.
@en
Conformational dynamics is key ...... on by pharmacological ligands.
@nl
type
label
Conformational dynamics is key ...... on by pharmacological ligands.
@en
Conformational dynamics is key ...... on by pharmacological ligands.
@nl
prefLabel
Conformational dynamics is key ...... on by pharmacological ligands.
@en
Conformational dynamics is key ...... on by pharmacological ligands.
@nl
P2093
P2860
P50
P356
P1433
P1476
Conformational dynamics is key ...... on by pharmacological ligands.
@en
P2093
Eduardo Salido
Encarnación Medina-Carmona
Julian E Fuchs
Noel Mesa-Torres
P2860
P2888
P356
10.1038/SREP20331
P407
P577
2016-02-03T00:00:00Z