"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
about
Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical spaceOne-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acidsN-substituted glutamyl sulfonamides as inhibitors of glutamate carboxypeptidase II (GCP2).Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-onesFormal [4+3] epoxide cascade reaction via a complementary ambiphilic pairing strategy.Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions.A formal [4 + 4] complementary ambiphile pairing reaction: a new cyclization pathway for ortho-quinone methidesMicrowave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy.Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocolApplication of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.Chemistry of bridged lactams and related heterocyclesSynthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategyExploring chemical diversity via a modular reaction pairing strategySynthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol.Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxidesA summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.Synthesis of cyclic 1,3-diols as scaffolds for spatially directed librariesModular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams.Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reactionStereochemical and skeletal diversity arising from amino propargylic alcohols.Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.Metathesis Cascade Strategies (ROM-RCM-CM): A DOS approach to Skeletally Diverse Sultams.Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Diversity-oriented synthesis of bicyclic and tricyclic alkaloids
P2860
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P2860
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
description
2009 nî lūn-bûn
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
@zh-hk
2009年論文
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2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
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name
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@en
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@nl
type
label
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@en
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@nl
prefLabel
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@en
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@nl
P2093
P2860
P356
P1433
P1476
"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.
@en
P2093
Aihua Zhou
Dinesh Rayabarapu
Paul R Hanson
P2860
P304
P356
10.1021/OL802467F
P407
P577
2009-02-01T00:00:00Z