Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.
about
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNATyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).The use of divalent metal ions by type II topoisomerases.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageDirect measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplificationAll tangled up: how cells direct, manage and exploit topoisomerase function.Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalphaTopoisomerase-mediated chromosomal break repair: an emerging player in many games.Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer.Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer.
P2860
Q24305044-5D257AB7-59EE-4502-ADC7-BD3CE75B14F9Q33875792-E2ECB44D-C39C-4424-9CC6-69D0B318683DQ34054930-57D247CE-A637-414E-A391-216E29452001Q34909651-2338B895-E4D7-4DAA-A91B-D2F34E0512E0Q35120752-8D5FD1F3-47B9-4AB2-9D06-275AB0997DD6Q35154537-A88A6193-98B8-485F-BFC8-E289350BE8E6Q37435105-794EDEED-4214-4C05-8826-6F5A801AE098Q38360744-85FDB54B-4C44-4028-88D4-047748FCC42BQ38780013-97DED643-D86E-4C4A-939A-E6E65D889B25Q51350568-BF1FD1F3-70EA-4ED4-A591-72579576B3E4
P2860
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Coordinating the two protomer ...... s as topoisomerase II poisons.
@en
Coordinating the two protomer ...... s as topoisomerase II poisons.
@nl
type
label
Coordinating the two protomer ...... s as topoisomerase II poisons.
@en
Coordinating the two protomer ...... s as topoisomerase II poisons.
@nl
prefLabel
Coordinating the two protomer ...... s as topoisomerase II poisons.
@en
Coordinating the two protomer ...... s as topoisomerase II poisons.
@nl
P2860
P356
P1433
P1476
Coordinating the two protomer ...... s as topoisomerase II poisons.
@en
P2093
Neil Osheroff
P2860
P304
P356
10.1021/BI8021679
P407
P577
2009-02-01T00:00:00Z