The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.
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The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringIntegrin α1 Has a Long Helix, Extending from the Transmembrane Region to the Cytoplasmic Tail in Detergent MicellesA novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionPIP kinases define PI4,5P₂signaling specificity by association with effectorsKindlins, integrin activation and the regulation of talin recruitment to αIIbβ3.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesMultiscale simulations suggest a mechanism for integrin inside-out activation.Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution.Subcellular localization of talin is regulated by inter-domain interactionsNMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.Talin activates integrins by altering the topology of the β transmembrane domainMultiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes.Membrane Association of the Diphtheria Toxin Translocation Domain Studied by Coarse-Grained Simulations and ExperimentAtomic-level description of protein-lipid interactions using an accelerated membrane model.A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.Molecular mechanism of inside-out integrin regulationPerspective on the Martini model.Mechanisms of talin-dependent integrin signaling and crosstalkTalin and kindlin: the one-two punch in integrin activation.Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations.Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.Interactions of the auxilin-1 PTEN-like domain with model membranes result in nanoclustering of phosphatidyl inositol phosphatesTalin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase.Defining the membrane-associated state of the PTEN tumor suppressor protein.Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface.Interactions of peripheral proteins with model membranes as viewed by molecular dynamics simulations.Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.The integrin-talin complex under force.Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function.
P2860
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P2860
The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The structure of the talin/int ...... n NMR and MD simulation study.
@en
The structure of the talin/int ...... n NMR and MD simulation study.
@en-gb
The structure of the talin/int ...... n NMR and MD simulation study.
@nl
type
label
The structure of the talin/int ...... n NMR and MD simulation study.
@en
The structure of the talin/int ...... n NMR and MD simulation study.
@en-gb
The structure of the talin/int ...... n NMR and MD simulation study.
@nl
prefLabel
The structure of the talin/int ...... n NMR and MD simulation study.
@en
The structure of the talin/int ...... n NMR and MD simulation study.
@en-gb
The structure of the talin/int ...... n NMR and MD simulation study.
@nl
P2093
P2860
P1433
P1476
The structure of the talin/int ...... n NMR and MD simulation study.
@en
P2093
Benjamin T Goult
Iain D Campbell
Kate L Wegener
Mark S P Sansom
Nicholas J Anthis
P2860
P304
P356
10.1016/J.STR.2010.07.012
P577
2010-10-01T00:00:00Z