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Predicting new molecular targets for known drugsAntiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.Pediatric drug safety signal detection: a new drug-event reference set for performance testing of data-mining methods and systems.Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine.Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride.Modification of K+ channel-drug interactions by ancillary subunits.Role of the pH in state-dependent blockade of hERG currents.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.Drug trapping in hERG K+ channels: (not) a matter of drug size?Drug-induced hERG block and long QT syndrome.Revealing the structural basis of action of hERG potassium channel activators and blockers.Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function.New Trends in Cancer Therapy: Targeting Ion Channels and Transporters.Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors.Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.Molecular determinants of hERG channel block by terfenadine and cisapride.Gating charge movement precedes ionic current activation in hERG channels.Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.Trapping and dissociation of propafenone derivatives in HERG channels.hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: implications for drug safety assessment.In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.Inhibition of cloned hERG potassium channels by risperidone and paliperidone.High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment.Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
State dependent dissociation of HERG channel inhibitors
@en
State dependent dissociation of HERG channel inhibitors
@nl
type
label
State dependent dissociation of HERG channel inhibitors
@en
State dependent dissociation of HERG channel inhibitors
@nl
prefLabel
State dependent dissociation of HERG channel inhibitors
@en
State dependent dissociation of HERG channel inhibitors
@nl
P2093
P2860
P356
P1476
State dependent dissociation of HERG channel inhibitors
@en
P2093
S Berjukow
P2860
P304
P356
10.1038/SJ.BJP.0707356
P407
P577
2007-06-25T00:00:00Z