Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
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Production of novel rapamycin analogs by precursor-directed biosynthesis.Leafy gall formation is controlled by fasR, an AraC-type regulatory gene in Rhodococcus fasciansGenetics of zwittermicin a production by Bacillus cereusThe 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systemsCrystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoKComparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathwaysCloning and characterization of the genes encoding a cytochrome P450 (PipA) involved in piperidine and pyrrolidine utilization and its regulatory protein (PipR) in Mycobacterium smegmatis mc2155.Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases.Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus.Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies.The enzymes of β-lactam biosynthesis.Characterization of interactions between the transcriptional repressor PhlF and its binding site at the phlA promoter in Pseudomonas fluorescens F113.FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensisBiosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismateBiosynthesis of rapamycin and its regulation: past achievements and recent progress.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.The regulation of the secondary metabolism of Streptomyces: new links and experimental advances.Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.An overview of rapamycin: from discovery to future perspectives.Oxidative Cyclization in Natural Product BiosynthesisIdentification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation.Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes.Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensisA gene for a dioxygenase-like protein determines the production of the DF signal in Xanthomonas campestris pv. campestris.Secondary metabolism in simulated microgravity.New rapamycin derivatives by precursor-directed biosynthesis.Engineering Corynebacterium glutamicum for fast production of L-lysine and L-pipecolic acid.SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus.A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.The Two Translationally Controlled Tumor Protein Genes, CsTCTP1 and CsTCTP2, Are Negative Modulators in the Cucumis sativus Defense Response to Sphaerotheca fuliginea.
P2860
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P2860
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Organisation of the biosynthet ...... nking the polyketide synthase.
@en
Organisation of the biosynthet ...... nking the polyketide synthase.
@nl
type
label
Organisation of the biosynthet ...... nking the polyketide synthase.
@en
Organisation of the biosynthet ...... nking the polyketide synthase.
@nl
prefLabel
Organisation of the biosynthet ...... nking the polyketide synthase.
@en
Organisation of the biosynthet ...... nking the polyketide synthase.
@nl
P2093
P1433
P1476
Organisation of the biosynthet ...... nking the polyketide synthase.
@en
P2093
J F Aparicio
J Staunton
S F Haydock
T Schwecke
P356
10.1016/0378-1119(95)00799-7
P407
P577
1996-02-01T00:00:00Z