Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
about
The hitchhiker's guide to the voltage-gated sodium channel galaxyModal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunitsModulation of skeletal muscle sodium channels by human myotonin protein kinase.Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.Interaction between the sodium channel inactivation linker and domain III S4-S5.Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin.A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switchEvolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes.Structure and function of voltage-gated sodium channels.A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linkerA mutation in segment IVS6 disrupts fast inactivation of sodium channelsComputational biology in the study of cardiac ion channels and cell electrophysiology.Mutually exclusive action of cationic veratridine and cevadine at an intracellular site of the cardiac sodium channelMolecular analysis of the putative inactivation particle in the inactivation gate of brain type IIA Na+ channels.Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channelInactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel.Interaction between the pore and a fast gate of the cardiac sodium channel.Anomalous effect of permeant ion concentration on peak open probability of cardiac Na+ channels.Effect of alkali metal cations on slow inactivation of cardiac Na+ channels.Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linkerA cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.Molecular modeling and dynamics of the sodium channel inactivation gate.The kinetics of voltage-gated ion channels.A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore.N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix.Negatively charged residues adjacent to IFM motif in the DIII-DIV linker of hNa(V)1.4 differentially affect slow inactivation.Exchange of conduction pathways between two related K+ channels.Negative charges in the DIII-DIV linker of human skeletal muscle Na+ channels regulate deactivation gating.Sequence analysis of the knockdown resistance-homologous region of the para-type sodium channel gene from pyrethroid-resistant Boophilus microplus (Acari: Ixodidae).
P2860
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P2860
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@en
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@nl
type
label
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@en
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@nl
prefLabel
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@en
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@nl
P2093
P356
P1433
P1476
Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.
@en
P2093
P304
P356
10.1126/SCIENCE.2173138
P407
P577
1990-11-01T00:00:00Z