Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.
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Genome sequence of the human malaria parasite Plasmodium falciparumStructure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathwayStructure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development.New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in PlasmodiumIsoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesThe crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.Current development in isoprenoid precursor biosynthesis and regulationFragment screening of infectious disease targets in a structural genomics environmentHeterologous expression and characterization of two 1-hydroxy-2-naphthoic acid dioxygenases from Arthrobacter phenanthrenivorans.Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspFParasite plastids: maintenance and functionsMechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax.Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coliThe Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Methylerythritol phosphate pathway of isoprenoid biosynthesis.Biochemistry of the non-mevalonate isoprenoid pathway.Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum.Isoprenoid metabolism in apicomplexan parasites.Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis.Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes.2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activityTemperature response of isoprene emission in vivo reflects a combined effect of substrate limitations and isoprene synthase activity: a kinetic analysis.Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum
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Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum.
description
2001 nî lūn-bûn
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2001年の論文
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name
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@en
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@nl
type
label
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@en
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@nl
prefLabel
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@en
Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@nl
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Biosynthesis of terpenoids. 2C ...... F) from Plasmodium falciparum.
@en
P2093
C A Schuhr
J Wungsintaweekul
W Eisenreich
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P304
P356
10.1046/J.1432-1327.2001.02204.X
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P577
2001-06-01T00:00:00Z