Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.
about
Biosynthesis of isoprenoids in plants: Structure of the 2C-methyl-d-erithrytol 2,4-cyclodiphosphate synthase fromArabidopsis thaliana. Comparison with the bacterial enzymesThe structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discoveryA Structure-Based Approach to Ligand Discovery for 2 C -Methyl- d -erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy †A triclinic crystal form ofEscherichia coli4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structureCrystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessmentFusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungiCyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesMetabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production.The non-mevalonate pathway of isoprenoid precursor biosynthesis.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Methylerythritol phosphate pathway of isoprenoid biosynthesis.Mechanistic aspects of carotenoid biosynthesis.Experimental evidence validating the computational inference of functional associations from gene fusion events: a critical survey.A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activityAbsence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway.Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway.Design of novel ligands of CDP-methylerythritol kinase by mimicking direct protein-protein and solvent-mediated interactions.
P2860
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P2860
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
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2004年學術文章
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2004年學術文章
@zh-hant
name
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@en
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@nl
type
label
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@en
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@nl
prefLabel
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@en
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@nl
P2093
P2860
P50
P356
P1476
Hexameric assembly of the bifu ...... renoid precursor biosynthesis.
@en
P2093
Felix Rohdich
Irene Hallyburton
Stefan Hecht
William N Hunter
Wolfgang Eisenreich
P2860
P304
52753-52761
P356
10.1074/JBC.M408895200
P407
P577
2004-10-02T00:00:00Z