Structure of the G60A mutant of Ras: implications for the dominant negative effect.
about
Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamicsStructure of the Dominant Negative S17N Mutant of Ras ,Structural Basis for Conformational Dynamics of GTP-bound Ras ProteinCrystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutantsStructure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)A potent lead induces apoptosis in pancreatic cancer cellsMolecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in CrystalCharacterization of a Ras mutant with identical GDP- and GTP-bound structuresThe role of conserved waters in conformational transitions of Q61H K-ras.Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.Fluorescence detection of GDP in real time with the reagentless biosensor rhodamine-ParM.Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformersMapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.Pocket-based drug design: exploring pocket spaceMapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins.The Kinesin-1 tail conformationally restricts the nucleotide pocketLessons from computer simulations of Ras proteins in solution and in membraneCurrent status of the development of Ras inhibitors.Direct Modulation of Small GTPase Activity and Function.Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics.Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.Relation between the conformational heterogeneity and reaction cycle of Ras: molecular simulation of Ras.Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1.Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions.Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.Exceptionally high-affinity Ras binders that remodel its effector domain.Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer.An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A.
P2860
Q27335812-95C57846-3B32-454E-A295-B8741BB9619AQ27659511-1D4BAD95-BFE1-48FE-9A7D-3B4245F4ABEAQ27661719-1A5D96AA-0BE7-4D36-ACB5-794B8D0467A9Q27679084-33EFABF3-593D-41F6-A6C6-F8BE9426B260Q27682320-77BD8BE9-9562-4B34-AC7F-AE30614DDE0FQ28480566-6B503A08-8953-484B-B21C-396BA32084BEQ31096214-93BEACC3-9219-4E66-8EF4-031C51B639E3Q34160318-DE3AA4F0-53ED-4B18-BC1C-C2D60EC59938Q34167863-C05D9A35-65CF-4F3D-9A46-D59601B1311FQ34868860-C5A9B07E-023A-4F0C-A1B2-9D7887CE4DBCQ35485376-17A53A66-08D3-4BA3-A47A-09E4B1566962Q35604462-E14DE256-44ED-45D5-BE00-69C183D0382DQ35760976-5E0DBE5A-3E6C-4662-B075-EB4CFE29CD82Q36502439-671F3C27-B380-419E-9B46-1101366FD5CEQ36846569-41C0AECB-366E-48B0-AC4D-09054B3D0D2EQ37263164-C0F0B460-644C-449E-B87E-06D26FD1C95FQ37301995-D37DB4C7-0F7C-425D-8E9A-C24CC6C50403Q38534932-7D9F721D-60C7-4E8E-8333-535DC12A9CF4Q38608107-312EE8D1-E706-4D88-AA54-7AAD0A8D51FEQ38990013-9D742604-C9AB-442B-B3B7-A7AB8F92D461Q39604170-DA51AB56-0FE9-4867-B621-D6A4BBAB89F9Q40325189-87E320F9-5BD5-4F76-93DC-848C05561F03Q41129970-0AD16A9C-C4FB-4F9F-9583-9845D43521B3Q41153386-E6C9BF6A-558E-40EF-A72D-99FA01EECD8AQ41870698-0BDB5650-1F6E-4493-9171-E828D62A02B2Q42049635-42C1CCA1-BBD7-4043-B015-B03B7557C5A4Q42159319-C19B82A6-DA2E-4C39-ACAB-E303A4457E33Q42918070-283CEDB4-4E18-45C4-B38D-A4066E8DD41EQ46107918-09A7D74F-3735-4D7B-A5AA-BC3B1D637D53Q46913684-6FAD2C1D-5611-47D5-87B8-402E506B9DE8Q47251052-EC49F38F-A590-4BB3-A408-1CF061D5B48CQ50355595-EF157A94-25D4-43AC-A816-E37827D38026Q53711959-73C2480E-9618-47FB-8F15-5879AD53CC18Q55253300-C334BF3F-AB79-45B4-AEE2-43113C97D7AA
P2860
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@en
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@nl
type
label
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@en
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@nl
prefLabel
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@en
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@nl
P2093
P356
P1476
Structure of the G60A mutant of Ras: implications for the dominant negative effect.
@en
P2093
Bradley Ford
Karlheinz Skowronek
Nicolas Nassar
Sean Boykevisch
P304
25697-25705
P356
10.1074/JBC.M502240200
P407
P577
2005-05-05T00:00:00Z