A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance.
about
The ABCs of Candida albicans Multidrug Transporter Cdr1The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicansCandida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistanceThe transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansEfflux in fungi: la pièce de résistanceTAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicansPopulation genomics of drug resistance in Candida albicans.Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles.Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.Regulatory circuitry governing fungal development, drug resistance, and disease.Azole resistance by loss of function of the sterol Δ⁵,⁶-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulenceCellular and molecular biology of Candida albicans estrogen response.A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicansGenome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates.Inhibition of nucleic acid biosynthesis makes little difference to formation of amphotericin B-tolerant persisters in Candida albicans biofilmFunctional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding siteGenotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.An update on antifungal targets and mechanisms of resistance in Candida albicans.Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks.Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transportDe-repression of CSP-1 activates adaptive responses to antifungal azoles.A fungal family of transcriptional regulators: the zinc cluster proteinsTetracycline effects on Candida albicans virulence factors.Multidrug resistance in fungiReversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification.Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistanceRelative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistanceMutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi.Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulenceAzole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor.CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.The global regulator Ncb2 escapes from the core promoter and impacts transcription in response to drug stress in Candida albicans.Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans.
P2860
Q26786747-57EA3A7B-9A18-4896-A7AB-E5B5E21E7BA1Q28469346-4F351EE2-990E-45D3-A0B8-9FC362DEC371Q28475025-39355DE4-7CBA-4CF1-8E10-9A134C09CAFFQ28477254-ABEABF0C-0304-4A3D-BFB5-CBDC8D4E6DA3Q33474798-E20F9753-4314-430C-AB01-0E7712A9FFFEQ33559776-C00C283C-EE34-44E6-8062-82AAC3AA01FEQ33826488-1D72A6C8-9D65-4437-9BAF-3E0B0C430606Q34034817-469E39BE-3AB4-4115-B1A0-9D01E3EF2F57Q34141180-45E92E07-BB77-4ED4-8FB9-341407B8D595Q34142347-2FE8BEFB-87E9-4187-AA41-44D7EACB206FQ34190284-AB1CCBDB-F532-4488-A4F6-C6A620824EFBQ34247781-3F32347F-AE42-493F-BFDE-60037A38A514Q34333968-B13D7E13-2AF2-4EAA-8A9F-2A3FFA37EF41Q34588684-280C93B0-2ED1-4B0E-A446-1816595635C3Q34887876-E514DC8D-C3DD-413C-96E5-137825CF11DFQ35076919-C8E3A916-563B-40DF-B5A4-CF3C478C4C86Q35191806-FE1FD701-9AB0-4572-81CF-8A49B8236D09Q35216756-AE7903B7-E50F-4696-B9FB-17BAA157A83BQ36095337-10550901-3DFD-4AAB-9F6A-3ADC8E82F821Q36235037-35765291-6542-42E2-A0E8-76567EA2DC3AQ36314156-07989930-4238-4A62-B47D-FD7E2293048CQ36423326-05D85142-CB81-4D8E-9350-53BE72441966Q36483019-BFE5014D-5AFB-4617-9088-E337666B2933Q36500088-DFDA3F60-72CF-4579-92C4-B67853E02662Q36588772-B7DCBDB2-9C55-4B82-AB63-4DBB677435F2Q36691600-6BA3C741-B252-40C3-939B-19356514D9D1Q36943181-5E7229F4-1ABB-4380-A8AF-61140855E784Q36990987-F6919F53-ECDD-4038-B24C-AF8EA6470E50Q37072109-6F6CF93B-3B5E-483B-A1D7-20BBC1423D30Q37122826-B0D383F4-286A-401E-84AC-98FC28EB6DD1Q37144914-19CBF767-392B-4BCB-B4DF-04E27778F3B5Q37183937-89E71DAA-0DA9-4E3C-A837-EBED6520054CQ37301949-8B9B9DDE-1D44-4357-B1CC-BFE733A941A7Q37371189-A76D3B23-E7D0-4436-80B0-8D940BA8A19AQ37545098-B30EFD8A-D691-4CEB-BDFC-7AFADEA0300FQ37568906-90062D2E-AD8C-477A-8159-B4B588A86006Q37625361-773C5122-3F90-43D6-A800-3C309149C8F8Q37629735-D660F7B0-7153-445A-9576-E6BEA120955EQ37739596-A0471AF9-0F7F-443F-8BC2-1AA874C2E5D4Q38155848-40066564-AB2B-48D6-9094-FA8DBA307DD9
P2860
A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
A common drug-responsive eleme ...... in antifungal drug resistance.
@en
A common drug-responsive eleme ...... in antifungal drug resistance.
@nl
type
label
A common drug-responsive eleme ...... in antifungal drug resistance.
@en
A common drug-responsive eleme ...... in antifungal drug resistance.
@nl
prefLabel
A common drug-responsive eleme ...... in antifungal drug resistance.
@en
A common drug-responsive eleme ...... in antifungal drug resistance.
@nl
P2093
P2860
P1476
A common drug-responsive eleme ...... in antifungal drug resistance.
@en
P2093
Christoph Schueller
Jacques Bille
Michelle de Micheli
P2860
P304
P356
10.1046/J.1365-2958.2002.02814.X
P407
P577
2002-03-01T00:00:00Z