The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.
about
A discrete alcohol pocket involved in GIRK channel activationThe evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptorsHigh-resolution structure of the open NaK channelStructure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gatingThe role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.Cholesterol binding to ion channelsTransfer of beta subunit regulation from high to low voltage-gated Ca2+ channels.Molecular determinants of gating at the potassium-channel selectivity filter.SLO-2 isoforms with unique Ca(2+) - and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinismThe pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.Structural locus of the pH gate in the Kir1.1 inward rectifier channel.Specificity of activation by phosphoinositides determines lipid regulation of Kir channels.Mutations of the membrane-bound disulfide reductase DsbD that block electron transfer steps from cytoplasm to periplasm in Escherichia coli.Role of conserved glycines in pH gating of Kir1.1 (ROMK)Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment.A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.New roles for a key glycine and its neighboring residue in potassium channel gating.G beta gamma and KACh: old story, new insights.Gating mechanism of KATP channels: function fits form.Potassium channels.Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase CThe molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel.Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission.A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreThe cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.Identification of functionally critical residues in the channel domain of inositol trisphosphate receptorsInvestigating the putative glycine hinge in Shaker potassium channel.Phosphoinositides alter lipid bilayer properties.The pore of voltage-gated potassium ion channels is strained when closed.The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.G protein βγ subunits: central mediators of G protein-coupled receptor signaling.Identification of novel cholesterol-binding regions in Kir2 channels.Elucidation of the gating of the GIRK channel using a spectroscopic approach.
P2860
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P2860
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The (beta)gamma subunits of G ...... ng of a transmembrane segment.
@en
type
label
The (beta)gamma subunits of G ...... ng of a transmembrane segment.
@en
prefLabel
The (beta)gamma subunits of G ...... ng of a transmembrane segment.
@en
P2093
P1433
P1476
The (beta)gamma subunits of G ...... ng of a transmembrane segment.
@en
P2093
Diomedes E Logothetis
Kim W Chan
Luying Peng
Roberto Sanchez
Taihao Jin
Tibor Rohacs
Tooraj Mirshahi
P304
P356
10.1016/S1097-2765(02)00659-7
P577
2002-09-01T00:00:00Z