Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain
about
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cellsTargeting protein lipidation in diseaseEndosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment.Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.Differential transformation capacity of Src family kinases during the initiation of prostate cancer.Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase.Cholesterol in platelet biogenesis and activation.Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites.The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions.Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.Regulation of the SRC family kinases by Csk.PAG--a multipurpose transmembrane adaptor protein.Src family kinases: at the forefront of platelet activationMicroRNAs as the fine-tuners of Src oncogenic signalling.Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse modelFer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression.P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade.Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions.Overexpression of Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains induces cluster of differentiation 59-mediated apoptosis in Jurkat cells.Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
P2860
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P2860
Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Transforming potential of Src ...... -enriched membrane microdomain
@en
Transforming potential of Src ...... -enriched membrane microdomain
@nl
type
label
Transforming potential of Src ...... -enriched membrane microdomain
@en
Transforming potential of Src ...... -enriched membrane microdomain
@nl
prefLabel
Transforming potential of Src ...... -enriched membrane microdomain
@en
Transforming potential of Src ...... -enriched membrane microdomain
@nl
P2093
P2860
P356
P1476
Transforming potential of Src ...... -enriched membrane microdomain
@en
P2093
Akira Ogawa
Chitose Oneyama
Kazunobu Saito
Kei Suzuki
Masato Okada
Takuya Iino
P2860
P304
P356
10.1128/MCB.00941-09
P407
P577
2009-10-12T00:00:00Z