Multifunctional specificity of the protein C/activated protein C Gla domain. - Wikidata - awgldk - TriplyDB

Multifunctional specificity of the protein C/activated protein C Gla domain.

Multifunctional specificity of the protein C/activated protein C Gla domain.

http://www.wikidata.org/entity/Q42692755

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FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men Cytoprotective-selective activated protein C therapy for ischaemic stroke Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.Activated protein C action in inflammation Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.Regulation of the protein C anticoagulant and antiinflammatory pathways.Endothelial cell protein C receptor: a multiliganded and multifunctional receptor Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIa Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection.Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor.Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells.Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa.Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays Heterozygous congenital Factor VII deficiency with the 9729del4 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C Factor VIIa binding to endothelial cell protein C receptor.Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium.Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications.Species-specific anticoagulant and mitogenic activities of murine protein S.Down-regulation of the clotting cascade by the protein C pathway Tissue factor and cell signalling in cancer progression and thrombosis.The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling.A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective PAR1 signaling.One amino acid in mouse activated factor VII defines its endothelial protein C receptor (EPCR) binding and modulates its EPCR-dependent hemostatic activity in vivo.Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor.Endothelial protein C receptor is required for tissue factor ternary complex signaling in the mouse.Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa.Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment.The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.

P2860

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P2860

Multifunctional specificity of the protein C/activated protein C Gla domain.

http://www.wikidata.org/entity/Q42692755

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Multifunctional specificity of the protein C/activated protein C Gla domain.

@en

Multifunctional specificity of the protein C/activated protein C Gla domain.

@nl

type

label

Multifunctional specificity of the protein C/activated protein C Gla domain.

@en

Multifunctional specificity of the protein C/activated protein C Gla domain.

@nl

prefLabel

Multifunctional specificity of the protein C/activated protein C Gla domain.

@en

Multifunctional specificity of the protein C/activated protein C Gla domain.

@nl

P1433

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P1476

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P2093

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P2860

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P698

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P356

P1433

Journal of Biological Chemistry

P1476

Multifunctional specificity of the protein C/activated protein C Gla domain

@en

P2093

Björn Dahlbäck

http://www.w3.org/2001/XMLSchema#string

Cristina Razzari

http://www.w3.org/2001/XMLSchema#string

David A Lane

http://www.w3.org/2001/XMLSchema#string

Eva Ajzner

http://www.w3.org/2001/XMLSchema#string

Sonia Dua

http://www.w3.org/2001/XMLSchema#string

Stalo Karageorgi

http://www.w3.org/2001/XMLSchema#string

P2860

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

The crystal structure of the endothelial protein C receptor and a bound phospholipid

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins

Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR

Characterization of a cDNA coding for human protein C

Efficacy and safety of recombinant human activated protein C for severe sepsis

Screening the molecular surface of human anticoagulant protein C: a search for interaction sites.

Modeling zymogen protein C.

P304

28850-28857

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P31

scholarly article

P356

10.1074/JBC.M604966200

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P407

P433

39

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P478

281

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P50

P577

2006-07-25T00:00:00Z

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P5875

6918318

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P698

16867987

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