about
Axial coordination of NHC ligands on dirhodium(II) complexes: generation of a new family of catalysts.Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineeringStudies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene.Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.A rapid, site-selective and efficient route to the dual modification of DARPins.The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.Bromomaleimide-linked bioconjugates are cleavable in mammalian cellsA HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy.Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.Optical control of trimeric P2X receptors and acid-sensing ion channelsA novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment.TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cellsChemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.Generalized epilepsies: emerging insights into cellular and genetic mechanisms.Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate.Next-generation disulfide stapling: reduction and functional re-bridging all in one.Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate.Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.Synthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes.A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids--an unusual 1,2-phenyl shift.3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides.An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones.Diastereomer configurations from joint experimental-computational analysis.Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: relevance to catalytic amination.Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids.Studies on high-temperature amination reactions of aromatic chlorides using discrete palladium-N-heterocyclic carbene (NHC) complexes and in situ palladium/imidazolium salt protocols.Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin.Unusual reactivity of a nickel N-heterocyclic carbene complex: tert-butyl group cleavage and silicone grease activation.
P50
Q31154450-C1769D60-EE5C-4D34-B6DF-7833B22972B1Q33428434-FEB27F7D-6059-4AEF-8AD7-92CE2E5EEF5EQ33582517-E6D66BEA-A773-44BA-AE37-617E54F730AAQ33587970-F25034C4-6F9B-4F90-98E5-9B3CD5B7E209Q33748314-EAAEC18C-049B-4AE3-8253-28FC4C77C0A2Q33785374-BB971B9D-D7F7-4E3C-9E13-5B321EC27510Q33879313-F357344D-FDB1-4948-B3D4-BB0703CB4296Q35216471-7A9DC4AF-274B-484A-915C-75FD83C9ECB0Q35873697-F86B03A5-B2A4-41B7-8AC4-B98738CB1B03Q36097775-4E19C06E-FCF1-49AA-AC06-87117DD70C43Q36708427-035E79FD-E984-4035-9D63-B6BDB23AD086Q37475069-13518393-F956-4CC9-BF07-AFCF19B4DC6BQ38728279-F0A57987-B769-449F-BBEC-188983EC380EQ38837846-7942F42C-F815-4F47-B5F0-63A4D1624F89Q38892876-610BCE23-70B2-4B43-9A16-EA98EE4E1D6AQ39021423-FFE92000-8E23-4AAB-946A-51DFFE57EC6AQ39448837-37A70EBC-3256-4766-8519-AE8CBD1820F3Q40643359-D4893FC9-581B-427C-A6DB-C0CF422790E7Q41467750-21852BCC-D6A4-4343-87EE-93C78F518250Q41550170-78A3DFCE-2DE5-4299-BDFF-7150136E4D20Q41773582-888C3213-21D6-4086-9787-077D5F86601DQ41834335-3C4F54FD-A4AB-4439-8A30-B91EB0427599Q42095021-71107A58-C008-440F-8A0F-9AF4D91FE726Q42165953-6C592476-CB2D-422B-AF7C-850F9D7CDDA1Q42585968-BF3B0513-84D8-4955-B207-AE73F72E1B2FQ42699301-A299B3EC-F97C-4F1B-8408-A80357B47CF3Q42871498-64349442-C7D1-4056-A73B-306A27EB1AE4Q43070952-475FDE99-7370-414E-9275-46F0B4CF78E3Q43154296-937EE73F-6B03-4736-8B33-659D7CEE0124Q43213667-009F155A-8334-4103-ACDB-13B9A2FA6742Q43261172-CF2EC136-A56A-4FD5-8AF5-D825FD73E794Q43292695-15E145CC-8DF1-497D-BC5E-B6676E8CA377Q43487759-26663D1D-7009-4D2F-BFB1-45A1F10A7C73Q44546596-681C2D50-84B0-4A6D-8D36-B7165B0A35FBQ44588616-3D2DF1FE-C286-4D65-8994-CED0B5B55E37Q44628600-C7F34A0A-428D-41BD-B7DF-2DE642ADD905Q44744374-D442744A-426D-4A50-92C3-4275B3F76D34Q44761028-C06C8354-C68E-44EC-AD9D-3B1C82DC66FCQ45039911-5743F3D9-7662-41B8-A5AA-5A99F1E89231Q45137640-64E52755-C34A-4CA7-BFAA-41B035AC04F6
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Stephen Caddick
@ast
Stephen Caddick
@en
Stephen Caddick
@es
Stephen Caddick
@nl
Stephen Caddick
@sl
type
label
Stephen Caddick
@ast
Stephen Caddick
@en
Stephen Caddick
@es
Stephen Caddick
@nl
Stephen Caddick
@sl
prefLabel
Stephen Caddick
@ast
Stephen Caddick
@en
Stephen Caddick
@es
Stephen Caddick
@nl
Stephen Caddick
@sl
P1053
B-8550-2009
P106
P21
P31
P3829
P496
0000-0002-3267-7302