Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.
about
Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic targetDevelopment and Evaluation of a Fluorescent Antibody-Drug Conjugate for Molecular Imaging and Targeted Therapy of Pancreatic CancerEnabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineeringClick chemistry patents and their impact on drug discovery and chemical biology.Emerging formats for next-generation antibody drug conjugates.Chemical Protein Modification through Cysteine.Towards the next generation of biomedicines by site-selective conjugation.Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome.Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development.Next-generation disulfide stapling: reduction and functional re-bridging all in one.A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.Thiomaleimide Functionalization for Selective Biological Fluorescence Detection of Peroxynitrite as Tested in HeLa and RAW 264.7 Cells.Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.A novel coelenterate luciferin-based luminescent probe for selective and sensitive detection of thiophenols.Modification of Cysteine.Dibromomaleimide as a facile, versatile linker for delivery applications.Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.Disulfide conjugation chemistry: a mixed blessing for therapeutic drug delivery?Construction of homogeneous antibody-drug conjugates using site-selective protein chemistryWater-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides
P2860
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P2860
Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Next generation maleimides ena ...... ative disulfide bond bridging.
@en
Next generation maleimides ena ...... ative disulfide bond bridging.
@nl
type
label
Next generation maleimides ena ...... ative disulfide bond bridging.
@en
Next generation maleimides ena ...... ative disulfide bond bridging.
@nl
prefLabel
Next generation maleimides ena ...... ative disulfide bond bridging.
@en
Next generation maleimides ena ...... ative disulfide bond bridging.
@nl
P2093
P2860
P50
P356
P1476
Next generation maleimides ena ...... ative disulfide bond bridging.
@en
P2093
Antoine Maruani
Felix F Schumacher
João P M Nunes
Kerry A Chester
Mark E B Smith
P2860
P304
P356
10.1039/C4OB01550A
P577
2014-10-01T00:00:00Z