Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function
about
Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase βUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayDNA polymerase β contains a functional nuclear localization signal at its N-terminus.Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Translesion DNA polymerases and cancerInsertion of oxidized nucleotide triggers rapid DNA polymerase openingStrategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced CytotoxicityUnderstanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.Genome instability caused by a germline mutation in the human DNA repair gene POLB.Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis.
P2860
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P2860
Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Systematic biochemical analysi ...... teration of enzymatic function
@en
Systematic biochemical analysi ...... teration of enzymatic function
@nl
type
label
Systematic biochemical analysi ...... teration of enzymatic function
@en
Systematic biochemical analysi ...... teration of enzymatic function
@nl
prefLabel
Systematic biochemical analysi ...... teration of enzymatic function
@en
Systematic biochemical analysi ...... teration of enzymatic function
@nl
P2093
P2860
P356
P1433
P1476
Systematic biochemical analysi ...... teration of enzymatic function
@en
P2093
Chang Long An
Desheng Chen
Nick M Makridakis
P2860
P304
P356
10.1002/HUMU.21465
P577
2011-03-01T00:00:00Z