about
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesisKnocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities.Visualization of sialyl Lewis(X) glycosphingolipid microdomains in model membranes as selectin recognition motifs using a fluorescence label.Cooperation between lateral ligand mobility and accessibility for receptor recognition in selectin-induced cell rolling.Hydrophilic/Hydrophobic balance determines morphology of glycolipids with oligolactose headgroups.Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture.Membrane adhesion via homophilic saccharide-saccharide interactions investigated by neutron scattering.Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.Synthesis of dimeric lactose and dimeric (sialyl) Lewis(X) glycolipids.A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.Lessons learned from clustering of fluorinated glycolipids on selectin ligand function in cell rolling.Functional microdomains of glycolipids with partially fluorinated membrane anchors: impact on cell adhesion.RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345.Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.Frontiers in Medicinal Chemistry 2009--a summary of the meeting at Heidelberg University.Oligomer-to-polymer transition in short ethylene glycol chains connected to mobile hydrophobic anchors.Identification and biological evaluation of thiazole-based inverse agonists of RORγt.Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742.Modulation of intermembrane interaction and bending rigidity of biomembrane models via carbohydrates investigated by specular and off-specular neutron scatteringGrazing-Incidence Neutron-Induced Fluorescence Probes Density Profiles of Labeled Molecules at Solid/Liquid InterfacesCalcium-Dependent Carbohydrate-Carbohydrate Recognition between Lewis(X) Blood Group Antigens This research was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen IndustrieTotal synthesis of the natural antigen involved in the hyperacute rejection response to xenotransplantsDiscovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritisRetinoid-related orphan receptor γ t modulators: comparison of Glenmark's me-too patent application (WO2015008234) with the originator application from Merck Sharp and Dohme (WO2012106995)Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγtCarbohydrate-Carbohydrate Recognition between LewisX GlycoconjugatesNonsteroidal FXR Ligands: Current Status and Clinical Applications
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Christian Gege
@ast
Christian Gege
@en
Christian Gege
@es
Christian Gege
@nl
Christian Gege
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type
label
Christian Gege
@ast
Christian Gege
@en
Christian Gege
@es
Christian Gege
@nl
Christian Gege
@sl
prefLabel
Christian Gege
@ast
Christian Gege
@en
Christian Gege
@es
Christian Gege
@nl
Christian Gege
@sl
P106
P21
P31
P496
0000-0002-0512-2774