Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
about
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivoChanges in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblastsGenomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkeyIdentification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylaseDivergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts.Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delayMalformation syndromes caused by disorders of cholesterol synthesis.Evolution of retinoid and steroid signaling: vertebrate diversification from an amphioxus perspective.Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.Genome-wide association between single nucleotide polymorphisms with beef fatty acid profile in Nellore cattle using the single step procedure.Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor.Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain.Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival.Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiaeDemonstrated and inferred metabolism associated with cytosolic lipid droplets.The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily.Steroidal triterpenes of cholesterol synthesis.A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells.Target deletion of the bifunctional type 12 17β-hydroxysteroid dehydrogenase in mice results in reduction of androgen and estrogen levels in heterozygotes and embryonic lethality in homozygotes.Differential expression and co-expression gene networks reveal candidate biomarkers of boar taint in non-castrated pigs.Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner.Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis.Enhanced expression of a biosimilar monoclonal antibody with a novel NS0 platform.4-methylcholesta-8(9);24-dien-3-one is reduced to 4-methylcholesta-8(9);24-dien-3beta-olZymosterone (cholesta-8(9);24-dien-3-one) is reduced to zymosterol (cholesta-8(9);24-dien-3beta-ol)Calretinin Participates in Regulating Steroidogenesis by PLC-Ca2+-PKC Pathway in Leydig Cells.Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.Homology Inference Based on a Reconciliation Approach for the Comparative Genomics of ProtozoaTumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions
P2860
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P2860
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
description
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im September 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/09/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/09/01)
@nl
наукова стаття, опублікована у вересні 2003
@uk
مقالة علمية (نشرت في سبتمبر 2003)
@ar
name
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@ast
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@en
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@nl
type
label
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@ast
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@en
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@nl
prefLabel
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@ast
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@en
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@nl
P2093
P356
P1476
Closing the gap: identificatio ...... alian cholesterol biosynthesis
@en
P2093
Bettina Husen
Daniela Laubner
Gabriele Moller
Jerzy Adamski
Zrinka Marijanovic
P304
P356
10.1210/ME.2002-0436
P577
2003-09-01T00:00:00Z