Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
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mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in RatsThe mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophreniaPerspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptorMolecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationAllosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family.Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to LightComputational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled ReceptorsPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsTherapeutic potential of targeting glutamate receptors in Parkinson's disease.In the grey zone between epilepsy and schizophrenia: alterations in group II metabotropic glutamate receptors.1,3,5-Trisubstituted Pyrazoles as Potent Negative Allosteric Modulators of the mGlu2/3 Receptors.Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators.Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics.
P2860
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P2860
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@en
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@nl
type
label
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@en
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@nl
prefLabel
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@en
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@nl
P2093
P356
P1476
Pharmacological characterizati ...... radioligand [3H]JNJ-40068782.
@en
P2093
Abdel Ahnaou
Anton Megens
Cindy Wintmolders
Frank M Dautzenberg
Gregor Macdonald
Hilde Lavreysen
Ilse Biesmans
Ilse Van der Linden
John R Atack
Jose Ignacio Andrés
P304
P356
10.1124/JPET.113.204990
P407
P577
2013-06-13T00:00:00Z