Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
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Structural insights into HDAC6 tubulin deacetylation and its selective inhibitionDevelopment of a histone deacetylase 6 inhibitor and its biological effectsInsecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprinaDiscovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activityA novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.Augmenting antitumor immune responses with epigenetic modifying agents.Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acidsBicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth DiseaseRational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.Creation of a histone deacetylase 6 inhibitor and its biological effects [corrected].Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy.Histone deacetylase 6 in health and disease.Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors.Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.HDACs and HDAC Inhibitors in Cancer Development and Therapy.Selective histone deacetylase small molecule inhibitors: recent progress and perspectives.Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules.Copper-catalysed oxidative C-H/N-H cross-coupling between formamides and amides through chelation-assisted N-H activation.Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.A potent hydroxamic acid-based, small-molecule inhibitor A452 preferentially inhibits HDAC6 activity and induces cytotoxicity toward cancer cells irrespective of p53 status.Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.Searching the conformational complexity and binding properties of HDAC6 through docking and molecular dynamic simulations.mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.Iron-catalyzed urea synthesis: dehydrogenative coupling of methanol and amines.Histone deacetylase 6 in cancer
P2860
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P2860
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Selective histone deacetylase ...... inhibit melanoma cell growth.
@en
Selective histone deacetylase ...... inhibit melanoma cell growth.
@nl
type
label
Selective histone deacetylase ...... inhibit melanoma cell growth.
@en
Selective histone deacetylase ...... inhibit melanoma cell growth.
@nl
prefLabel
Selective histone deacetylase ...... inhibit melanoma cell growth.
@en
Selective histone deacetylase ...... inhibit melanoma cell growth.
@nl
P2093
P2860
P356
P1476
Selective histone deacetylase ...... s inhibit melanoma cell growth
@en
P2093
Alan P Kozikowski
Eduardo M Sotomayor
Joel A Bergman
Karrune Woan
Patricio Perez-Villarroel
P2860
P304
P356
10.1021/JM301098E
P407
P577
2012-10-23T00:00:00Z