A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
about
Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive AntagonismSize-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Lysophospholipid receptor nomenclature review: IUPHAR Review 8.Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.Profound methyl effects in drug discovery and a call for new C-H methylation reactions.Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple SclerosisSphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist.Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fireFine-tuning S1P therapeuticsIntercellular Lipid Mediators and GPCR Drug DiscoveryModulators of the Sphingosine 1-phosphate receptor 1.The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Targeting sphingosine-1-phosphate signaling for cancer therapy.The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodesGradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response.Palladium(II)-catalyzed ortho-C-H arylation/alkylation of N-benzoyl α-amino ester derivatives.
P2860
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P2860
A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
A potent and selective S1P
@nl
A potent and selective S1P(1) ...... autoimmune encephalomyelitis.
@en
type
label
A potent and selective S1P
@nl
A potent and selective S1P(1) ...... autoimmune encephalomyelitis.
@en
prefLabel
A potent and selective S1P
@nl
A potent and selective S1P(1) ...... autoimmune encephalomyelitis.
@en
P2093
P1476
A potent and selective S1P(1) ...... autoimmune encephalomyelitis.
@en
P2093
Birgit Bollbuck
Christian Beerli
Christian Bruns
Daniela Angst
Danilo Guerini
Frédéric Berst
Jean Quancard
Klaus Seuwen
Marc Bigaud
Markus Streiff
P304
P356
10.1016/J.CHEMBIOL.2012.07.016
P577
2012-09-01T00:00:00Z