Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
about
Chemical probes of histone lysine methyltransferasesCancer epigenetics drug discovery and development: the challenge of hitting the markEpigenetic modulators as therapeutic targets in prostate cancerStrategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small moleculesRecent progress in the discovery of small-molecule inhibitors of the HMT EZH2 for the treatment of cancer.A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation.De novo peptide design and experimental validation of histone methyltransferase inhibitors.Selective inhibitors of protein methyltransferasesEZH2 as a potential target in cancer therapy.Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancerHIV-1 transcription and latency: an update.Development of multiple cell-based assays for the detection of histone H3 Lys27 trimethylation (H3K27me3).Targeting EZH2 for cancer therapy: progress and perspective.EZH2, an epigenetic driver of prostate cancer.Activating somatic mutations in diffuse large B-cell lymphomas: lessons from next generation sequencing and key elements in the precision medicine era.Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens.Aberrant overexpression of EZH2 and H3K27me3 serves as poor prognostic biomarker for esophageal squamous cell carcinoma patients.Orchestration of H3K27 methylation: mechanisms and therapeutic implication.Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2Screening-based translation of public research encounters painful problems.
P2860
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P2860
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Development and validation of ...... osome high-throughput screens.
@en
Development and validation of ...... osome high-throughput screens.
@nl
type
label
Development and validation of ...... osome high-throughput screens.
@en
Development and validation of ...... osome high-throughput screens.
@nl
prefLabel
Development and validation of ...... osome high-throughput screens.
@en
Development and validation of ...... osome high-throughput screens.
@nl
P2093
P2860
P356
P1476
Development and validation of ...... osome high-throughput screens.
@en
P2093
Andrew J Pope
Baochau Le
Benjamin Schwartz
Caretha L Creasy
Carl A Machutta
Christopher Nixon
Danielle Key
Elsie Diaz
Glenn Hofmann
Glenn S Van Aller
P2860
P304
P356
10.1177/1087057112453765
P577
2012-08-17T00:00:00Z