about
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptorPotential roles of GPR120 and its agonists in the management of diabetesOmega-3 Fatty Acids and FFAR4The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsFatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells.Making Dimethylamino a Transformable Directing Group by Nickel-Catalyzed C-N Borylation.Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84.Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release.Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsThe pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismEndogenous metabolites as ligands for G protein-coupled receptors modulating risk factors for metabolic and cardiovascular disease.Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.The therapeutic potential of GPR120: a patent review.Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors.Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research.FFA4/GPR120 agonists: a survey of the recent patent literature.G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.Investigational insulin secretagogues for type 2 diabetes.Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development.Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells.Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue.The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).Free Fatty Acid Receptors and Cancer: From Nutrition to Pharmacology.FFA4/GPR120: Pharmacology and Therapeutic Opportunities.Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets.Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice.Docosahexaenoic acid mechanisms of action on the bovine oocyte-cumulus complex.Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal β-arrestin phosphosensor in Raw 264.7 macrophages.The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Discovery of a potent and selective GPR120 agonist.
@en
Discovery of a potent and selective GPR120 agonist.
@nl
type
label
Discovery of a potent and selective GPR120 agonist.
@en
Discovery of a potent and selective GPR120 agonist.
@nl
prefLabel
Discovery of a potent and selective GPR120 agonist.
@en
Discovery of a potent and selective GPR120 agonist.
@nl
P50
P356
P1476
Discovery of a potent and selective GPR120 agonist
@en
P2093
Christine Kiel Hovgaard
Graeme Milligan
P304
P356
10.1021/JM300215X
P407
P577
2012-05-02T00:00:00Z