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BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemEnzymatic degradation of carboxymethyl cellulose hydrolyzed by the endoglucanases Cel5A, Cel7B, and Cel45A from Humicola insolens and Cel7B, Cel12A and Cel45Acore from Trichoderma reesei.Sample preparation effects in matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry of partially depolymerised carboxymethyl cellulose.Sample preparation effects in matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry of partially depolymerised methyl cellulose.Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.Analytical approaches to improved characterization of substitution in hydroxypropyl cellulose.Amyloid-β metabolism in Niemann-Pick C disease models and patients.Development of a size exclusion chromatography method for the determination of molar mass for poloxamers.Improved matrix-assisted laser desorption/ionisation sample preparation of a partially depolymerised cellulose derivative by continuous spray deposition and interfacing with size-exclusion chromatography.Derivatization using dimethylamine for tandem mass spectrometric structure analysis of enzymatically and acidically depolymerized methyl cellulose.Enzyme-aided investigation of the substituent distribution in cationic potato amylopectin starch.Improved chemical analysis of cellulose ethers using dialkylamine derivatization and mass spectrometry.Characterization of chemical substitution of hydroxypropyl cellulose using enzymatic degradation.New approaches to the analysis of enzymatically hydrolyzed methyl cellulose. Part 1. Investigation of the influence of structural parameters on the extent of degradation.New approaches to the analysis of enzymatically hydrolyzed methyl cellulose. Part 2. Comparison of various enzyme preparations.Comprehensive analysis of the substituent distribution in hydroxyethyl celluloses by quantitative MALDI-ToF-MS.An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid.Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry.Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid.Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS methodSynthesis aided structural determination of amyloid-β(1-15) glycopeptides, new biomarkers for Alzheimer's disease.SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease.Heteromers of amyloid precursor protein in cerebrospinal fluid.Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluidThe amyloid-β degradation pattern in plasma--a possible tool for clinical trials in Alzheimer's disease.Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls.The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease.Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry.Clinical proteomics in neurodegenerative disorders.The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease.Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases.CSF Presenilin-1 complexes are increased in Alzheimer's diseaseExplorative and targeted neuroproteomics in Alzheimer's disease.Expanding the cerebrospinal fluid endopeptidome.Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease.A novel pathway for amyloid precursor protein processing.Targeting synaptic pathology with a novel affinity mass spectrometry approach.Substituent distribution and clouding behavior of hydroxypropyl methyl cellulose analyzed using enzymatic degradation.
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description
Zweeds onderzoeker
@nl
hulumtues
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researcher
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հետազոտող
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name
Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
@nl
Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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Gunnar Brinkmalm
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P106
P1153
6602971570
P21
P27
P31
P496
0000-0001-6958-2393