Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method
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Biophysical characterization of α-synuclein and its controversial structureExploring the accessible conformations of N-terminal acetylated α-synucleinLoss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein foldingMechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescenceThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseQuantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directionsα-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomerSNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease.Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications.N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sampleRecent advances in applying mass spectrometry and systems biology to determine brain dynamics.Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Cognitive decline in Parkinson disease.Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation.To be disordered or not to be disordered: is that still a question for proteins in the cell?N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer.Targeting synaptic pathology with a novel affinity mass spectrometry approach.Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure.Cerebrospinal fluid α-synuclein levels in Parkinson's disease--changed or unchanged?E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
P2860
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P2860
Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@ast
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@en
type
label
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@ast
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@en
prefLabel
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@ast
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@en
P2093
P2860
P50
P1476
Identification of novel α-synu ...... ine nanoLC-ESI-FTICR-MS method
@en
P2093
Anders Wallin
Annika Ohrfelt
Dzemila Secic
Ezra Mulugeta
Kerstin Andersson
Paul T Francis
Rita Persson
P2860
P2888
P304
P356
10.1007/S11064-011-0527-X
P50
P577
2011-06-16T00:00:00Z
P5875
P6179
1052665653