about
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradationPurification and identification of endogenous polySUMO conjugatesSUMO protease SENP1 induces isomerization of the scissile peptide bondStructure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysisPolymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex.System-wide changes to SUMO modifications in response to heat shock.Comparative proteomic analysis identifies a role for SUMO in protein quality control.Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selectionRole of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugationIn vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategySUMO and transcriptional regulationSUMOylation of the GTPase Rac1 is required for optimal cell migration.Predicting the impact of Lynch syndrome-causing missense mutations from structural calculationsQuantitative analysis of multi-protein interactions using FRET: application to the SUMO pathwayFRET-based in vitro assays for the analysis of SUMO protease activities.High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties.Identification of a substrate recognition site on Ubc9.Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.Detection of protein SUMOylation in vivoA fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processingThe S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Michael Tatham
@ast
Michael Tatham
@en
Michael Tatham
@es
Michael Tatham
@nl
Michael Tatham
@sl
type
label
Michael Tatham
@ast
Michael Tatham
@en
Michael Tatham
@es
Michael Tatham
@nl
Michael Tatham
@sl
prefLabel
Michael Tatham
@ast
Michael Tatham
@en
Michael Tatham
@es
Michael Tatham
@nl
Michael Tatham
@sl
P106
P1153
7003635344
P21
P31
P496
0000-0001-6986-1691