about
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligandTherapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014).Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders.Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.Melatonin receptor agonists: new options for insomnia and depression treatment.Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy.Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands.MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives.Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors.Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists.2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.Synthesis and biological activity of new melatonin dimeric derivatives.Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives.N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands.Synthesis of new C-6 alkyliden penicillin derivatives as beta-lactamase inhibitors.Synthesis and biological evaluation of 6-bromo-6-substituted penicillanic acid derivatives as beta-lactamase inhibitors.Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities.Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes.Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues.An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT(2) melatonin receptor antagonist.Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor.Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states.Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification.(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.Iridium-catalyzed direct synthesis of tryptamine derivatives from indoles: exploiting n-protected β-amino alcohols as alkylating agents.Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.Synthesis and configuration determination of all enantiopure stereoisomers of the melatonin receptor ligand 4-phenyl-2-propionamidotetralin using an expedient optical resolution of 4-phenyl-2-tetralone.Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the RabbitTowards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moietiesSynthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of IndolesDirect, One-Pot Reductive Alkylation of Anilines with Functionalized Acetals Mediated by Triethylsilane and TFA. Straightforward Route for Unsymmetrically Substituted Ethylenediamine
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Q28567937-800DE669-E41B-40A1-AB1C-F04DF34660D5Q34457651-39C6D2B2-780B-4ADE-AC50-A20F0C8A4AE4Q34588133-DB7F2887-D194-4ABE-AFF5-7E3A121DF445Q34720409-DBBCEF35-CDC7-4EEF-BCAC-7EE16BB879EBQ34803259-73582232-D6AA-4C76-944C-D6683B409486Q37763715-3C6976CC-11CD-44D3-8B98-6DD28D93A1EEQ37873581-D21B3DCC-0F2E-41EE-AE0C-FE2EEDFB52BEQ38467876-C232159D-6743-4FDF-ACA9-E48C66BFC950Q39128977-BFBD3FC0-AD06-4FF2-8CE0-0F47F587197EQ42716227-CD328E23-4F7C-42DE-BDED-0DD99CD48A34Q42725493-A7CBFFC0-1E32-47B7-802D-AB9D698BE7BDQ42807900-760D1D68-B76D-409E-B5A4-F8656F1048B2Q42813799-18D7BB0F-246C-41C5-B9A5-1932F06056F3Q42824016-20B9D2BB-686D-4F27-BEC8-5B655E67D09BQ42826612-8E31D724-1ED4-4A78-89E9-7878D8CF2C31Q42828605-7350D22C-7DD2-4CA7-B998-A30027A17051Q42828970-352A10C3-6169-49D7-A2DD-4E1E1BE9ABCEQ43182193-59165515-FE73-4447-A34B-1E8BDDF39003Q43281456-A930B738-BF4D-409B-AB1C-1400AA1BC003Q43979322-93F753BD-5F02-4FFC-AFE9-CF3A88FCAC76Q44165760-52ACAA46-EAAF-4197-BE7D-D9F18EF434F1Q44388140-3A4045E9-4873-4ACD-8FE6-039D8FC1461EQ44763557-D9287631-3837-4CAB-9D0F-9F848A1762A1Q45007066-57127F14-35C9-44B4-9B4D-232EEBDDE313Q45999860-97B2F88C-4BB8-4C1C-8761-DFD6979A27E3Q46510147-4B22D58C-A257-4892-817D-2DF418573E35Q46853883-ED3CD9AA-AD88-4537-A55D-D2405CE4A5CBQ46961858-0926DB6B-7A6A-417F-B30E-D0DFE9664969Q47928174-2DF1C5A9-51D2-4964-B628-84FB4805C222Q48132547-8B608D78-0A54-4F7E-AA65-0B30988B954FQ48147059-98DFA466-ED61-4FFB-9C8B-9D7CE60DD718Q48214810-C22A8BD2-6DE2-401D-B681-9646907F8C44Q48496246-89889591-64FF-4636-9D1B-94788A8E7BEAQ51006460-4D08F762-EC0D-4872-A0C6-B06AE442ECE4Q52623208-9AF9D080-38A9-4934-A4B4-B3F875EEB537Q53204974-C44182B7-F7E5-4F92-821E-6A9601731460Q61781536-4D5F7393-3C2B-4638-8AA5-9855AA9726DCQ61781541-03EDFD19-9B54-496F-98C5-28AC351CC7A9Q61781545-1E449ED2-8E91-4740-B2F4-6024EDE101CCQ61781548-BD2456AD-18EA-4FBA-928F-AF8A3D5CEFCF
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description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Annalida Bedini
@ast
Annalida Bedini
@en
Annalida Bedini
@es
Annalida Bedini
@nl
type
label
Annalida Bedini
@ast
Annalida Bedini
@en
Annalida Bedini
@es
Annalida Bedini
@nl
prefLabel
Annalida Bedini
@ast
Annalida Bedini
@en
Annalida Bedini
@es
Annalida Bedini
@nl
P106
P1153
56243856200
P21
P31
P496
0000-0002-9103-2918