about
Drug discovery targeting amino acid racemases.Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria.Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents.Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors.Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.Design and synthesis of novel isoxazole-based HDAC inhibitors.A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead.Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists.Inspired by Nature: The 3-Halo-4,5-dihydroisoxazole Moiety as a Novel Molecular Warhead for the Design of Covalent Inhibitors.Identification of a new series of amides as non-covalent proteasome inhibitors.Folates in Trypanosoma brucei: achievements and opportunitiesA Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted PyrrolesOne-pot chemoenzymatic synthesis of aldoximes from primary alcohols in waterRationalizing the Lacking of Inversion Symmetry in a Noncentrosymmetric Polar Racemate: An Experimental and Theoretical StudyUse of an o-Benzyl-(S)-Serine Containing Eluent for the Efficient Ligand-Exchange Chromatography-Based Enantioseparation of Constrained Glutamate Receptor LigandsEffects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 ExpressionAn efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharidesA new chemoenzymatic approach to the synthesis of Latanoprost and BimatoprostSweet-and-salty biocatalysis: Fructooligosaccharides production using Cladosporium cladosporioides in seawaterSynthesis and Pharmacological Evaluation of α4β2Nicotinic Ligands with a 3-Fluoropyrrolidine NucleusSynthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligandsEfficient synthesis of novel glutamate homologues and investigation of their affinity and selectivity profile at ionotropic glutamate receptorsSynthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptorsBiotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solventAn efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactorRegioselective Preparation of Functionalized Isoxazoline Derivatives as Key Intermediates for the Synthesis of Selective N-Methyl-d-aspartate Receptor AntagonistsSynthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptorsA highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl esterA novel simplified synthesis of acivicinA Regioselective Route to 5-Substituted Isoxazole- and Isoxazoline-3-phosphonatesSynthesis of new β- and γ-benzyloxy-S-glutamic acid derivatives and evaluation of their activity as inhibitors of excitatory amino acid transportersSynthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transportersA regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
ricercatrice
@it
հետազոտող
@hy
name
Lucia Tamborini
@ast
Lucia Tamborini
@en
Lucia Tamborini
@es
Lucia Tamborini
@nl
Lucia Tamborini
@sl
type
label
Lucia Tamborini
@ast
Lucia Tamborini
@en
Lucia Tamborini
@es
Lucia Tamborini
@nl
Lucia Tamborini
@sl
prefLabel
Lucia Tamborini
@ast
Lucia Tamborini
@en
Lucia Tamborini
@es
Lucia Tamborini
@nl
Lucia Tamborini
@sl
P214
P106
P1153
23983654000
P21
P214
P31
P396
IT\ICCU\CFIV\272796
P496
0000-0002-9755-7846
P569
1979-01-01T00:00:00Z
P735
P7859
viaf-307344301