Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers.
about
Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosomeLarge Scale Chemical Cross-linking Mass Spectrometry Perspectives.Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)A novel CXCR4-selective high-affinity fluorescent probe and its application in competitive binding assaysSite-directed mutations and the polymorphic variant Ala160Thr in the human thromboxane receptor uncover a structural role for transmembrane helix 4Quantitative analysis of T cell receptor complex interaction sites using genetically encoded photo-cross-linkers.Performance analysis of orthogonal pairs designed for an expanded eukaryotic genetic code.Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acidsAn in vivo photo-cross-linking approach reveals a homodimerization domain of Aha1 in S. cerevisiaePhoto-cross-linkers incorporated into G-protein-coupled receptors in mammalian cells: a ligand comparison.Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegansα-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers.Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.Genetically-encoded molecular probes to study G protein-coupled receptors.Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).Incorporation of Non-Canonical Amino Acids.Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification.HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer CellsAn expanded genetic code in Candida albicans to study protein-protein interactions in vivo.Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors.Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-L-phenylalanine.Expanding the genetic code in Xenopus laevis oocytes.Playing with the molecules of life.Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells.Genetically encoded photocrosslinkers as molecular probes to study G-protein-coupled receptors (GPCRs).
P2860
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P2860
Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers.
description
2011 nî lūn-bûn
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
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2011年論文
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2011年论文
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2011年论文
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2011年论文
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name
Mapping the ligand-binding sit ...... lly encoded photocrosslinkers.
@en
Mapping the ligand-binding site on a G protein-coupled receptor
@nl
type
label
Mapping the ligand-binding sit ...... lly encoded photocrosslinkers.
@en
Mapping the ligand-binding site on a G protein-coupled receptor
@nl
prefLabel
Mapping the ligand-binding sit ...... lly encoded photocrosslinkers.
@en
Mapping the ligand-binding site on a G protein-coupled receptor
@nl
P2093
P2860
P356
P1433
P1476
Mapping the ligand-binding sit ...... lly encoded photocrosslinkers.
@en
P2093
Amy Grunbeck
Pallavi Sachdev
Thomas Huber
P2860
P304
P356
10.1021/BI200214R
P407
P577
2011-04-07T00:00:00Z