Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
about
Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell MobilizationTurning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug developmentOdorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanismsElucidating a key component of cancer metastasis: CXCL12 (SDF-1α) binding to CXCR4.Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.The emerging role of CXC chemokines and their receptors in cancer.Development and characterization of pepducins as Gs-biased allosteric agonists.Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor MimeticsDrug discovery research targeting the CXC chemokine receptor 4 (CXCR4).Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.Immunological applications of stem cells in type 1 diabetes.Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.Pharmacological modulation of chemokine receptor function.The use of chemokine receptor agonists in stem cell mobilization.Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).Imaging agents for the chemokine receptor 4 (CXCR4).Kinetics of circulating progenitor cell mobilization during submaximal exercise.Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology.Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.Intracellular allosteric antagonism of the CCR9 receptor.Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A2B-receptor on blood cells.Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers.Agonists for the Chemokine Receptor CXCR4.Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis.G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin.Pharmacology: Inside-out receptor inhibition.G protein-coupled receptor modulation with pepducins: moving closer to the clinic
P2860
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P2860
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@ast
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@en
type
label
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@ast
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@en
prefLabel
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@ast
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
@en
P2093
P2860
P356
P1476
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells
@en
P2093
Adam O'Shea
Boris Tchernychev
Ed McBride
Jay M Janz
Kenneth E Carlson
Lynn Haggis
Manija A Kazmi
Pallavi Sachdev
Richard Looby
P2860
P304
22255-22259
P356
10.1073/PNAS.1009633108
P407
P577
2010-12-07T00:00:00Z