Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase.
about
Intrinsically disordered -subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structureStructural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunitIn vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.Determinants for phosphodiesterase 6 inhibition by its gamma-subunitComplementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin.Structural characterization of the rod cGMP phosphodiesterase 6.Interaction of rhodopsin with the G-protein, transducin.Molecular architecture of photoreceptor phosphodiesterase elucidated by chemical cross-linking and integrative modelingN-terminal half of the cGMP phosphodiesterase gamma-subunit contributes to stabilization of the GTPase-accelerating protein complexA truncated form of rod photoreceptor PDE6 β-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the γ-subunit.Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling.Detergents stabilize the conformation of phosphodiesterase 6.Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1).The retinal cGMP phosphodiesterase gamma-subunit - a chameleonMechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma-subunitsThe carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin.Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase.Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons.Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites.Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit.Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated.A point mutation uncouples transducin-alpha from the photoreceptor RGS and effector proteins.Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunits.An effector site that stimulates G-protein GTPase in photoreceptors.Identification of effector residues on photoreceptor G protein, transducin.Next-generation sequencing targeted disease panel in rod-cone retinal dystrophies in Māori and Polynesian reveals novel changes and a common founder mutation.The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure.An interface of interaction between photoreceptor cGMP phosphodiesterase catalytic subunits and inhibitory gamma subunits.Loss of the Effector Function in a Transducin-α Mutant Associated with Nougaret Night Blindness
P2860
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P2860
Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@en
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@nl
type
label
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@en
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@nl
prefLabel
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@en
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@nl
P2860
P356
P1433
P1476
Two-site high-affinity interac ...... cyclic GMP phosphodiesterase.
@en
P2093
N O Artemyev
P2860
P304
P356
10.1042/BJ2830273
P407
P478
283 ( Pt 1)
P577
1992-04-01T00:00:00Z