Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
about
Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF DomainPhosphodiesterase 6C, cGMP-specific cone alpha'.Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insightsCalcium sets the physiological value of the dominant time constant of saturated mouse rod photoresponse recovery.Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.Complementary interactions of the rod PDE6 inhibitory subunit with the catalytic subunits and transducin.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivationRod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.Characterization of conformational changes and protein-protein interactions of rod photoreceptor phosphodiesterase (PDE6).
P2860
Q27664639-41543837-105E-4D58-AE5A-EA3BAA9DBF93Q30380704-550F411E-E966-42C7-B8A1-8985E711B53BQ33571750-912A1DDD-1FB0-45BE-A597-F6DA75BDA705Q33707473-1042C684-40F1-45E4-B6CD-D28481AA59DDQ33717472-FB78BA28-CF41-45AF-A4C3-8CAF4C2B841AQ33832700-8B6A257C-DACA-4EB2-BFE1-99C290469B7FQ34765802-AD519788-A88A-4186-BF6D-D9BB54860D69Q34990373-8A15C285-DB0F-42DF-A706-769ED11402B1Q35311820-6444CA4F-97C8-4A80-9D18-716656B75CF1Q36016840-78B9E530-81A6-4C56-ABC9-72039BE628EF
P2860
Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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name
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@en
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@nl
type
label
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@en
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@nl
prefLabel
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@en
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@nl
P2093
P2860
P356
P1476
Direct allosteric regulation b ...... ceptor phosphodiesterase PDE6.
@en
P2093
Arye Elfenbein
Karyn B Cahill
Rick H Cote
Vadim Y Arshavsky
Xiu-Jun Zhang
P2860
P304
29699-29705
P356
10.1074/JBC.M803948200
P407
P577
2008-09-08T00:00:00Z