The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide
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The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrilsAmyloid fibrils derived from the apolipoprotein A1 Leu174Ser variant contain elements of ordered helical structureHuman apolipoprotein A-I natural variants: molecular mechanisms underlying amyloidogenic propensityThe crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment.Amyloidogenicity and clinical phenotype associated with five novel mutations in apolipoprotein A-I.Proteomics in protein misfolding diseases.Familial conformational diseases and dementias.NBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils.Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases.Conformational and aggregation properties of the 1-93 fragment of apolipoprotein A-I.Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies.Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis.Current perspectives on cardiac amyloidosis.Ostertag revisited: the inherited systemic amyloidoses without neuropathy.Structure, function and amyloidogenic propensity of apolipoprotein A-I.Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosisHereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 geneNovel strategies for the diagnosis and treatment of cardiac amyloidosis.Apolipoprotein A-I: the dual face of a protein.Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.Insights into the fate of the N-terminal amyloidogenic polypeptide of ApoA-I in cultured target cellsApolipoprotein A-1-related amyloidosis 2 case reports and review of the literature.Effects of a lipid environment on the fibrillogenic pathway of the N-terminal polypeptide of human apolipoprotein A-I, responsible for in vivo amyloid fibril formation.Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.Hepatic amyloidosis resulting from deposition of the apolipoprotein A-I variant Leu75Pro.Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein.Online registry for mutations in hereditary amyloidosis including nomenclature recommendations.Two different types of amyloid deposits--apolipoprotein A-IV and transthyretin--in a patient with systemic amyloidosis.Laryngeal presentation of systemic apolipoprotein A-I-derived amyloidosis.Amyloid formation: an emulation of matrix protein assembly?Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids.AApoAIL75P amyloidosis causes cirrhosis-like appearance of the liver in the absence of laboratory or clinical signs of hepatic dysfunctionOrgan Transplantation in Hereditary Apolipoprotein AI Amyloidosis
P2860
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P2860
The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@en
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@nl
type
label
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@en
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@nl
prefLabel
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@en
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@nl
P2093
P2860
P1476
The new apolipoprotein A-I var ...... residue N-terminal polypeptide
@en
P2093
M Stoppini
P Mangione
V Bellotti
P2860
P304
P356
10.1016/S0002-9440(10)65167-X
P407
P577
1999-09-01T00:00:00Z