about
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infectionPerturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sitesPeroxisomes are signaling platforms for antiviral innate immunityRegulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLLRab27a and Rab27b control different steps of the exosome secretion pathwayUnbiased reconstruction of a mammalian transcriptional network mediating pathogen responsesFull-length transcriptome assembly from RNA-Seq data without a reference genomeChromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammalsThe receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunityThe master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part oneFunctional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.Synaptotagmin-mediated vesicle fusion regulates cell migration.CRISPR-Cas9 knockin mice for genome editing and cancer modelingA Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian TranslationGenome-scale loss-of-function screening with a lentiviral RNAi library.Forward RNAi screens in primary human hematopoietic stem/progenitor cells.RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cellsCD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasisIn vivo discovery of immunotherapy targets in the tumour microenvironment.An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretionSystematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8bCommon genetic variants modulate pathogen-sensing responses in human dendritic cells.Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.SF3B1 and other novel cancer genes in chronic lymphocytic leukemiaIAP inhibitors enhance co-stimulation to promote tumor immunity.Principles and strategies for developing network models in cancer.Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Human systems immunology: hypothesis-based modeling and unbiased data-driven approaches.High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategiesEffective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans.Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cellsRNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory NetworksImmunogenetics. Dynamic profiling of the protein life cycle in response to pathogens
P50
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P50
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