Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.
about
A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling moleculesJunctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.Large-scale phosphotyrosine proteomic profiling of rat renal collecting duct epithelium reveals predominance of proteins involved in cell polarity determination.Regulation of adherens junction dynamics by phosphorylation switches.The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migrationBench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.Adherens Junction and E-Cadherin complex regulation by epithelial polarity.Umbilical cord blood-derived stromal cells regulate megakaryocytic proliferation and migration through SDF-1/PECAM-1 pathway.Modulation of the tumor suppressor protein alpha-catenin by ischemic microenvironment.Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
P2860
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P2860
Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@en
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@nl
type
label
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@en
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@nl
prefLabel
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@en
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@nl
P2860
P356
P1433
P1476
Modulation of alpha-catenin Ty ...... e constitutively active FGFR3.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209728
P407
P577
2006-06-12T00:00:00Z
P5875
P6179
1038420015