Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process.
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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisHuman cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleInvolvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatinProtein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitPreventing re-replication of chromosomal DNA.HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replicationTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsSpatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpointCdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterpartsCREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein.Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin.Replication licensing--defining the proliferative state?Replication licensing and the DNA damage checkpoint.Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycleDynamics of pre-replication complex proteins during the cell division cycleThe role of the replication licensing system in cell proliferation and cancer.p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer.Regulating DNA replication in eukarya.Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional controViral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication.Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation.Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogeneThe role and regulation of the preRC component Cdc6 in the initiation of premeiotic DNA replication.C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathwayThe DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication.Significance of DNA Replication Licensing Proteins (MCM2, MCM5 and CDC6), p16 and p63 as Markers of Premalignant Lesions of the Uterine Cervix: Its Usefulness to Predict Malignant PotentialSynchronous and Time-Dependent Expression of Cyclins, Cyclin-Dependant Kinases, and Apoptotic Genes in the Rumen Epithelia of Butyrate-Infused Goats.O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions
P2860
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P2860
Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@en
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@nl
type
label
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@en
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@nl
prefLabel
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@en
Chromatin-bound Cdc6 persists ...... clin A-cdk2 dependent process.
@nl
P2093
P1476
Chromatin-bound Cdc6 persists ...... yclin A-cdk2 dependent process
@en
P2093
P304
P407
P478
113 ( Pt 11)
P577
2000-06-01T00:00:00Z