Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.
about
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort proteinDeletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cellsSmgGDS displays differential binding and exchange activity towards different Ras isoformsBasis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factorsSites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras.A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation.Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathwaysInhibitors of Ras-SOS Interactions.TC21 causes transformation by Raf-independent signaling pathways.Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinomaNucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner.Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.Activation of R-Ras by Ras-guanine nucleotide-releasing factor.A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.GEF-mediated GDP/GTP exchange by monomeric GTPases: a regulatory role for Mg2+?Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.
P2860
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P2860
Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@en
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@nl
type
label
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@en
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@nl
prefLabel
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@en
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@nl
P2093
P2860
P356
P1476
Involvement of the switch 2 do ...... e nucleotide exchange factors.
@en
P2093
Campbell SL
Mosteller RD
Quilliam LA
P2860
P304
11076-11082
P356
10.1074/JBC.271.19.11076
P407
P577
1996-05-01T00:00:00Z