Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. - Wikidata - awgldk - TriplyDB

Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.

Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.

http://www.wikidata.org/entity/Q42813152

about

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6 The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells SmgGDS displays differential binding and exchange activity towards different Ras isoforms Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors Sites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras.A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation.Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways Inhibitors of Ras-SOS Interactions.TC21 causes transformation by Raf-independent signaling pathways.Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner.Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.Activation of R-Ras by Ras-guanine nucleotide-releasing factor.A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.GEF-mediated GDP/GTP exchange by monomeric GTPases: a regulatory role for Mg2+?Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.

P2860

Q22003726-7041C648-AC99-4E61-9EFC-B736DE894284 Q24657695-67CA667F-80B9-4620-A2B5-1783F16B0CB6 Q28145521-94F58D58-53C7-45D1-8FD9-A762CB114B6E Q28214447-A97EB6A9-A43E-41E4-B50B-F361AFF94D07 Q28216470-5F31A2DC-D867-4817-B1C1-7C4C95A3FBB4 Q31444366-377BFA6E-3747-4609-9976-1EE9ADFABE3E Q34428860-EF5F6A1F-772B-454F-A0E7-7B9B1E0F33A8 Q35847030-DA422CCE-F08D-4DD5-B612-DAC52C70ED99 Q35859222-F615FCEF-2005-435C-9EA5-98C5D27EA61F Q36563448-4446452B-2C1B-4B14-9289-43B35705E424 Q36975457-4E85E3BE-E266-4722-A901-B4F6AB0DAB1F Q37736492-D8749246-3840-4C4D-8661-7F6BB8661D5C Q39576948-2B2CDA5C-7932-440E-840E-DCF54603922D Q41069980-7CE1A9F2-3B8B-402E-A2EE-2D0F70B0D00D Q42061965-A6B930CB-42FF-4563-964D-5FFB17167FA8 Q42647708-7237ECF5-7AD9-4FB5-9ADA-DB207292F2F0 Q43232375-BFFE17E7-D6A7-4C07-B054-631EA27150D8 Q43595428-BD748A0D-8C40-4A0A-BDFA-D7B28BF2C056 Q47705912-1C888478-174E-4F5F-B558-91542A5730F8 Q54570559-E30C7181-9860-415D-AD26-8649F9F2CF53

P2860

Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.

http://www.wikidata.org/entity/Q42813152

description

1996 nî lūn-bûn

@nan

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

1996年论文

@zh

1996年论文

@zh-cn

name

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@en

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@nl

type

label

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@en

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@nl

prefLabel

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@en

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@nl

P1433

Q42813152-18C56AC6-CC17-44A9-802A-76185DAB958B

P1476

Q42813152-093E5145-77EF-4D4E-8C78-AEE8FDACCE1B

P2093

Q42813152-41D0E124-453D-4C9B-81D2-DF2AC2606D12

Q42813152-48EB58A2-3963-4608-9EDA-7F456053E1A2

Q42813152-4AE030B7-8CA1-4C25-B730-ED1568E82185

Q42813152-6A16F808-923E-4F85-BFEA-ABA793D7150F

Q42813152-72564EA6-8C07-4FF9-842B-1C2BA5E8E775

Q42813152-7D720D8B-51E2-418F-9D1E-424E80C77860

Q42813152-93A6FF99-5A2B-4AB1-848E-670E255B52C5

Q42813152-9B358973-8B9A-4E6F-B57E-B99F79FC5BA2

Q42813152-ED077740-4AA3-43C1-914B-A4233F953432

Q42813152-F1D92693-1CD9-476D-BC87-61D3227964E5

P2860

Q42813152-0680C20C-E203-4BE4-B1D9-6846B97A54D1

Q42813152-073BA625-791D-48C1-A50E-7C2BA9EB13A6

Q42813152-18E29ACD-EA59-4C39-8D5E-DC653E626393

Q42813152-2F66AC7E-08D4-44F1-AF34-76998925BCBC

Q42813152-36B6106E-789C-4529-90F4-F03E387C244A

Q42813152-36F1DF81-0D1F-45D1-99D2-6D74DE07C619

Q42813152-37124B44-FAFE-4D5B-A6A8-95930406BCA4

Q42813152-3C77E86A-2AD4-46F0-A949-E45EF7EB0CD1

Q42813152-44917EDF-A97D-4F91-BCFF-07418D5959AC

Q42813152-46EE581C-EC84-4E2A-A6E1-74638D15C891

P304

Q42813152-11453042-88BF-453C-BBBE-E2C43EDBE024

P31

Q42813152-DCBD1F55-FD08-4637-B495-4FAE10AFF765

P356

Q42813152-28E266CA-7958-4D43-9C0D-478442836368

P407

Q42813152-B027F05C-BD6E-44AC-A8E0-2A0712590066

P433

Q42813152-CF5B1032-F002-4F06-AF6C-A1F1791F8855

P478

Q42813152-94D0FEB3-DC7B-4B86-8594-3ADC3F246802

P577

Q42813152-06BA16ED-AA40-499E-9618-1B6F14EC7E8A

P5875

Q42813152-9B6855DA-19A1-43AA-B516-8EADCB682D37

P698

Q42813152-91A26F82-3659-4233-AC6F-8B850EB55906

P356

JBC.271.19.11076

P1433

Journal of Biological Chemistry

P1476

Involvement of the switch 2 do ...... e nucleotide exchange factors.

@en

P2093

Broek D

http://www.w3.org/2001/XMLSchema#string

Campbell SL

http://www.w3.org/2001/XMLSchema#string

Der CJ

http://www.w3.org/2001/XMLSchema#string

Drugan JK

http://www.w3.org/2001/XMLSchema#string

Han J

http://www.w3.org/2001/XMLSchema#string

Hisaka MM

http://www.w3.org/2001/XMLSchema#string

Lowry A

http://www.w3.org/2001/XMLSchema#string

Mosteller RD

http://www.w3.org/2001/XMLSchema#string

Quilliam LA

http://www.w3.org/2001/XMLSchema#string

Zhong S

http://www.w3.org/2001/XMLSchema#string

P2860

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy

The GTPase superfamily: conserved structure and molecular mechanism

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.

Construction and applications of a highly transmissible murine retrovirus shuttle vector.

Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.

P304

11076-11082

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.271.19.11076

http://www.w3.org/2001/XMLSchema#string

P407

P433

19

http://www.w3.org/2001/XMLSchema#string

P478

271

http://www.w3.org/2001/XMLSchema#string

P577

1996-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14573211

http://www.w3.org/2001/XMLSchema#string

P698

8626650

http://www.w3.org/2001/XMLSchema#string