Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factorsActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsStimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cellsGenetic interaction between Rb and K-ras in the control of differentiation and tumor suppressionSuprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathwayPhosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortexRas, an actor on many stages: posttranslational modifications, localization, and site-specified events.Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and developmentConcepts in Ras-directed therapy.A Ras by any other name.The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factorsSilencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritisRas isoform-specific signaling: location, location, location.The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology.Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycleRb and N-ras function together to control differentiation in the mouse.High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue.Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factorsSignal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1.H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses.Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases.Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase.Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.Activation of N-ras and K-ras induced by interleukin-6 in a myeloma cell line: implications for disease progression and therapeutic response.Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells.Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility.Functional specificity of ras isoforms: so similar but so different.Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization.Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements.The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase.Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors.Differential dynamics of RAS isoforms in GDP- and GTP-bound states.
P2860
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P2860
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
@en
type
label
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
@en
prefLabel
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
@en
P2860
P356
P1476
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.3.1782
P407
P577
1998-01-01T00:00:00Z