Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.

Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.

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http://www.wikidata.org/entity/Q42846145
X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivityThe 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognitionStructural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of  -Amyloid Precursor Protein-derived InhibitorStructural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexesA multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model.Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2).Computational insights into the selectivity mechanism of APP-IP over matrix metalloproteinases.Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.Solution structures of stromelysin complexed to thiadiazole inhibitors.Observation of exclusively π-stacked heterodimer of indole and hexafluorobenzene in the gas phase.Similarity of binding sites of human matrix metalloproteinases.Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins.Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya.
P2860

Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.

Item
http://www.wikidata.org/entity/Q42846145
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Structural characterizations o ...... s for stromelysin selectivity.
@en
Structural characterizations o ...... s for stromelysin selectivity.
@nl
type
label
Structural characterizations o ...... s for stromelysin selectivity.
@en
Structural characterizations o ...... s for stromelysin selectivity.
@nl
prefLabel
Structural characterizations o ...... s for stromelysin selectivity.
@en
Structural characterizations o ...... s for stromelysin selectivity.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Structural characterizations o ...... is for stromelysin selectivity
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932