Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. - Wikidata - awgldk - TriplyDB

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

http://www.wikidata.org/entity/Q42854967

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Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis MUTYH the base excision repair gene family member associated with colorectal cancer polyposis A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex Interactions Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer Role of inherited defects of MYH in the development of sporadic colorectal cancer Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese.Gastrointestinal tract cancers: Genetics, heritability and germ line mutations MUTYH Mutations Do Not Cause HNPCC or Late Onset Familial Colorectal Cancer Genomic and epigenetic instability in colorectal cancer pathogenesis.Lower gastrointestinal tract cancer predisposition syndromes The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.MUTYH Associated Polyposis (MAP).Identification of patients at risk for hereditary colorectal cancer Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage.Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis.MUTYH gene variants and breast cancer in a Dutch case–control study.ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes The genetics of FAP and FAP-like syndromes.Base excision repair, aging and health span.Molecular Genetics of Colorectal Cancer: An Overview DNA repair dysfunction in gastrointestinal tract cancers.Pathological features of colorectal carcinomas in MYH-associated polyposis.Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast MUTYH-associated colorectal cancer and adenomatous polyposis.Genetic association between hOGG1 C8069G polymorphism and colorectal cancer risk.Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer.Prevalence of MYH-associated polyposis related to three recurrent mutations in Morocco.The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis Base excision repair and the role of MUTYH MUTYH-associated polyposis (MAP), the syndrome implicating base excision repair in inherited predisposition to colorectal tumors.Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas.Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population.Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients.MYH mutations are rare in prostate cancer.Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients.Genetic alterations of the MYH gene in gastric cancer.Clinical and molecular detection of inherited colorectal cancers in northeast Italy: a first prospective study of incidence of Lynch syndrome and MUTYH-related colorectal cancer in Italy.

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P2860

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

http://www.wikidata.org/entity/Q42854967

description

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2003年の論文

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name

Germline mutations but not som ...... unselected colorectal cancers.

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Germline mutations but not som ...... unselected colorectal cancers.

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type

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Germline mutations but not som ...... unselected colorectal cancers.

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Germline mutations but not som ...... unselected colorectal cancers.

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Germline mutations but not som ...... unselected colorectal cancers.

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Germline mutations but not som ...... unselected colorectal cancers.

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The American Journal of Pathology

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Germline mutations but not som ...... unselected colorectal cancers

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Andrew J Rowan

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Huw J W Thomas

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Ian P M Tomlinson

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Kevin Pack

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Lara Lipton

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Sarah E R Halford

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Shirley V Hodgson

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Walter F Bodmer

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P2860

Instability and decay of the primary structure of DNA

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

APC mutations occur early during colorectal tumorigenesis

DNA base modifications in chromatin of human cancerous tissues

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

Endogenous mutagens and the causes of aging and cancer.

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