about
Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fynNogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localizationInteraction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase IIProtein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelinationInsulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alphaIsolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces.Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects.Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migrationPRL-3: a metastasis-associated phosphatase in search of a function.PRL PTPs: mediators and markers of cancer progression.Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Elevation of membrane tyrosine phosphatase activity in density-dependent growth-arrested fibroblasts.Protein tyrosine phosphatases in mast cell signaling.The interaction of protein-tyrosine phosphatase α (PTPα) and RACK1 protein enables insulin-like growth factor 1 (IGF-1)-stimulated Abl-dependent and -independent tyrosine phosphorylation of PTPα.TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.Tyrosine phosphatase PTPα contributes to HER2-evoked breast tumor initiation and maintenance.Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.A multifunctional calmodulin-stimulated phosphatase.YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.Reduced NMDA receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPalpha in NMDA receptor regulation.Insulin secretagogues activate the secretory granule receptor-like protein-tyrosine phosphatase IAR.Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes.Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.Interconversion of the kinetic identities of the tandem catalytic domains of receptor-like protein-tyrosine phosphatase PTPalpha by two point mutations is synergistic and substrate-dependent.PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function.Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety.Breaking the pain connection.Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.Integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase-alpha is required for cytoskeletal reorganization and cell migration.Localization of the genes encoding the type I diabetes autoantigens, protein-tyrosine phosphatases IA2 and IAR.Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.Pituitary-specific transcriptional initiation sites of the rat carboxypeptidase-H gene and the influence of thyroid hormone status.
P50
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P50
description
hulumtuese
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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Catherine J. Pallen
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P1153
7005924521
P21
P31
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0000-0002-3576-5295