Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?
about
The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsRegulation of platelet lifespan by apoptosis.Screening efficient BH3-mimetics to hBcl-B by means of peptidodynmimetic method.Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation.Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing.Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3Apoptosis regulation at the mitochondrial outer membrane.Mitochondria-mediated apoptosis in mammals.Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak.The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress.MOMP in the absence of BH3-only proteins.Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation.Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced deathA Bim-activating mouldExploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.
P2860
Q27010154-3B04040D-C271-4736-90B3-B534F6604DB4Q33431667-B6E0CEC8-F73E-4D7E-9DB4-F8477F16C162Q33457038-593D2A1E-6F99-4CAA-B8A7-80FB62F6F9CDQ35330220-0DFB4614-A887-4F92-BEBD-BCE64DDB6B08Q35805025-07314669-2842-467C-8055-5BF392BC5592Q36293251-1D182FDD-CA4F-440E-8B6B-25E6B6B45EEDQ37192687-CDAE5C91-05C2-417C-9D6E-37683BA3FC81Q38181031-5E6082DD-EFE7-4E0F-97E5-42C4F7D3BAA2Q38235124-91DFF114-F839-4CF7-A731-DA29CDEB7EF4Q38398064-E277727E-8C12-4053-B227-3A9DA2C35FB1Q39041000-7EEA0ACF-F681-41E8-9EBD-D1EEE43FF131Q39130935-164980AD-224C-4544-ADFC-98C2E4815F44Q40471316-22413FD9-F629-4FF7-A184-6BE6197012B7Q42087886-7399A2DC-18CB-43C9-9160-338F6A0F9F36Q42415116-B5090A32-7FFD-41C4-BE9A-8F77D4A4CE3AQ42601038-471172C6-FF87-42F2-AF17-58E0ED8CE815Q50911306-C01C15DE-B564-4F11-96DA-066C03E3F659Q55065352-CD54304A-FFF7-45B7-8ECA-EDF227F88BA0
P2860
Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@en
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@nl
type
label
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@en
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@nl
prefLabel
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@en
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@nl
P2860
P50
P356
P1476
Can the analysis of BH3-only p ...... ct' activation of Bax and Bak?
@en
P2093
A Villunger
P2860
P2888
P304
P356
10.1038/CDD.2011.100
P577
2011-10-01T00:00:00Z
P5875
P6179
1047840271