about
Total synthesis of (+/-)-morphineA novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagentsNovel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal PathwayAllosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generationTotal synthesis of (+)-vinblastine: control of the stereochemistry at C18'.Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation.Total synthesis of (-)-morphine.Total synthesis of (-)-mersicarpine.Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.Stereocontrolled total synthesis of (+)-vinblastine.Total synthesis of ecteinascidin 743.Synthesis of eudistomin C and E: improved preparation of the indole unit.(1-nosyl-5-nitroindol-3-yl)methyl ester: a novel protective group for carboxylic acids.Oseltamivir enhances hippocampal network synchronization.Total synthesis of (+)-lysergic acid.Total Syntheses of Aurachins A and B.Total Synthesis of (-)-Morphine.Activity-dependent proteolytic cleavage of neuroligin-1.Synthesis of Cardiopetaline via a Wagner-Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group.Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.Total Synthesis of Huperzine R.Total synthesis of (-)-lepistine.Formal Synthesis of Sarain A: Intramolecular Cycloaddition of an Eight-Membered Cyclic Nitrone to Construct the 2-Azabicyclo[3.3.1]nonane Framework.Total synthesis of (-)-anisatin.Identification of novel deoxyribofuranosyl indole antimicrobial agents.Total Synthesis of (-)-Tetrodotoxin and 11-norTTX-6(R)-ol.A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitorsSynthetic Studies of Isoschizogamine: Alternative Preparation of the Key IntermediateNew photocleavable linker: α-Thioacetophenone-type linkerEnantioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration This work was supported in part by the Ministry of Education, Sports, and Culture, Japan. S.Y. thanks the JSPS for a predoctoral fellowshipSynthesis of (+)-vinblastine and its analoguesConcise total synthesis of (+)-lyconadin AA practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amineTotal synthesis of (-)-salinosporamide ATotal synthesis of (-)-isoschizogamine
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Satoshi Yokoshima
@ast
Satoshi Yokoshima
@en
Satoshi Yokoshima
@es
Satoshi Yokoshima
@nl
Satoshi Yokoshima
@sl
type
label
Satoshi Yokoshima
@ast
Satoshi Yokoshima
@en
Satoshi Yokoshima
@es
Satoshi Yokoshima
@nl
Satoshi Yokoshima
@sl
prefLabel
Satoshi Yokoshima
@ast
Satoshi Yokoshima
@en
Satoshi Yokoshima
@es
Satoshi Yokoshima
@nl
Satoshi Yokoshima
@sl
P1053
I-6961-2014
P106
P31
P3829
P496
0000-0003-4036-0062