Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factorsTargeting Pim kinases for cancer treatment: opportunities and challengesEvidence that the Pim1 kinase gene is a direct target of HOXA9Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cellsGenetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.Reassessing the role of C-MYB in tumorigenesis.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients.RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development.PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.Integrated signaling in developing lymphocytes: the role of DNA damage responses.Lymphocyte development: integration of DNA damage response signaling.Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis.Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndromeHoxa9 regulates Flt3 in lymphohematopoietic progenitors.Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.Why target PIM1 for cancer diagnosis and treatment?Novel molecular mechanism for generating NK-cell fitness and memory.Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death.Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.Pim-1 regulates cardiomyocyte survival downstream of Akt.Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.Identification of the autophosphorylation sites of the Xenopus laevis Pim-1 proto-oncogene-encoded protein kinase.Evaluation of the Emu-pim-1 transgenic mouse model for short-term carcinogenicity testing.
P2860
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P2860
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@en
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@nl
type
label
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@en
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@nl
prefLabel
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@en
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@nl
P2093
P2860
P356
P1476
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.
@en
P2093
P2860
P304
P356
10.1084/JEM.178.5.1665
P407
P577
1993-11-01T00:00:00Z