about
Guidelines for the use and interpretation of assays for monitoring autophagyGenome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagyPINK1 cleavage at position A103 by the mitochondrial protease PARL.The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyMitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsEffects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model.Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Drosophila models of Parkinson's disease.Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.TRAP1 rescues PINK1 loss-of-function phenotypes.The PINK1/Parkin pathway: a mitochondrial quality control system?Molecular mechanisms of PINK1-related neurodegeneration.Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease.How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?The many faces of mitophagy.Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage.Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing.Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy.Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin.Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss.Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disordersInhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunctionThe STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator modelsMitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in DrosophilaAntioxidant Therapy in Parkinson's Disease: Insights from Drosophila melanogaster
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P50
description
hulumtues
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researcher
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հետազոտող
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name
Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J Whitworth
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Alexander Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
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Alexander J. Whitworth
@nl
P108
P106
P1153
8592831600
P21
P31
P496
0000-0002-1154-6629