Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin. - Wikidata - awgldk - TriplyDB

Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

http://www.wikidata.org/entity/Q42952032

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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?DNA modifications: function and applications in normal and disease States The emerging role of epigenetics in cardiovascular disease Regulation of chromatin structure in the cardiovascular system Epigenetics: a new mechanism of regulation of heart failure?Role of mecp2 in experience-dependent epigenetic programming Disease mutations in disordered regions--exception to the rule?Genetic modifiers of MeCP2 function in Drosophila.Rett syndrome: disruption of epigenetic control of postnatal neurological functions Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes.Targeted manipulation of heterochromatin rescues MeCP2 Rett mutants and re-establishes higher order chromatin organization.Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure.A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets.High levels of MeCP2 depress MHC class I expression in neuronal cells.The Crucial Role of DNA Methylation and MeCP2 in Neuronal Function Reconstitution of heterochromatin-dependent transcriptional gene silencing.Unique physical properties and interactions of the domains of methylated DNA binding protein 2.Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Recent advances in MeCP2 structure and function.MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination.The role of genetics in the establishment and maintenance of the epigenome.Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome.15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain.CAGE-defined promoter regions of the genes implicated in Rett Syndrome.MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain.Sequence features accurately predict genome-wide MeCP2 binding in vivo.Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

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P2860

Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

http://www.wikidata.org/entity/Q42952032

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@en

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@nl

type

label

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@en

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@nl

prefLabel

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@en

Multiple modes of interaction ...... g protein MeCP2 and chromatin.

@nl

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Molecular and Cellular Biology

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Multiple modes of interaction ...... ng protein MeCP2 and chromatin

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P2093

Christopher L Woodcock

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Jeffrey C Hansen

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Rachel A Horowitz-Scherer

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Tatiana Nikitina

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Xi Shi

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P2860

Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

How do site-specific DNA-binding proteins find their targets?

Rett syndrome and MeCP2: linking epigenetics and neuronal function

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin

Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain

The solution structure of the domain from MeCP2 that binds to methylated DNA

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864-877

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scholarly article

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10.1128/MCB.01593-06

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3

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27

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Rajarshi P Ghosh

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17101771

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1800686

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